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Rabbit Anti-CCL21 Recombinant Antibody (CBYY-C1076) (CBMAB-C2513-YY)

This product is rabbit antibody that recognizes CCL21. The antibody CBYY-C1076 can be used for immunoassay techniques such as: FC, WB
See all CCL21 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBYY-C1076
Antibody Isotype
IgG
Application
FC, WB

Basic Information

Immunogen
Protein corresponding to Human CCL21 (aa 24-134)
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
0.5 mg/mL
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-C Motif Chemokine Ligand 21
Entrez Gene ID
Human6366
Mouse298006
UniProt ID
HumanO00585
MouseQ5RJN3
Alternative Names
Cyclin A1; Testicular Tissue Protein Li 34; Cyclin-A1; CT146;
Function
Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Biological Process
Activation of GTPase activity Source: BHF-UCL
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cell chemotaxis Source: UniProtKB
Cell maturation Source: BHF-UCL
Cellular response to chemokine Source: BHF-UCL
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine (C-C motif) ligand 21 signaling pathway Source: BHF-UCL
Chemokine-mediated signaling pathway Source: GO_Central
Dendritic cell chemotaxis Source: BHF-UCL
Dendritic cell dendrite assembly Source: BHF-UCL
Eosinophil chemotaxis Source: GO_Central
Establishment of T cell polarity Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: UniProtKB
Immune response Source: ProtInc
Immunological synapse formation Source: BHF-UCL
Inflammatory response Source: GO_Central
Lilling of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Mesangial cell-matrix adhesion Source: BHF-UCL
Monocyte chemotaxis Source: GO_Central
Negative regulation of dendritic cell apoptotic process Source: BHF-UCL
Negative regulation of dendritic cell dendrite assembly Source: BHF-UCL
Negative regulation of leukocyte tethering or rolling Source: UniProtKB
Neutrophil chemotaxis Source: GO_Central
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of cell adhesion mediated by integrin Source: BHF-UCL
Positive regulation of cell-matrix adhesion Source: UniProtKB
Positive regulation of cell motility Source: BHF-UCL
Positive regulation of chemotaxis Source: BHF-UCL
Positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of filopodium assembly Source: BHF-UCL
Positive regulation of glycoprotein biosynthetic process Source: BHF-UCL
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
Positive regulation of JNK cascade Source: BHF-UCL
Positive regulation of myeloid dendritic cell chemotaxis Source: BHF-UCL
Positive regulation of neutrophil chemotaxis Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
Positive regulation of protein kinase activity Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of pseudopodium assembly Source: BHF-UCL
Positive regulation of receptor-mediated endocytosis Source: BHF-UCL
Positive regulation of T cell chemotaxis Source: BHF-UCL
Positive regulation of T cell migration Source: MGI
Release of sequestered calcium ion into cytosol Source: BHF-UCL
Response to prostaglandin E Source: BHF-UCL
Ruffle organization Source: BHF-UCL
T cell costimulation Source: BHF-UCL
Cellular Location
Secreted

Chen, Q., Yin, H., Pu, N., Zhang, J., Zhao, G., Wenhui, L., & Wu, W. (2021). CCL21 synergized with PD-L1 blockade restrains tumor growth. Cancer Science.

Chen, Q., Yin, H., Pu, N., Zhang, J., Zhao, G., Lou, W., & Wu, W. (2021). Chemokine C‐C motif ligand 21 synergized with programmed death‐ligand 1 blockade restrains tumor growth. Cancer science, 112(11), 4457-4469.

Cui, K., Zou, H., Shi, M., Ou, Y., Han, L., Zhang, B., ... & Li, S. (2020). Gene expression profiles in chemokine (CC Motif) Ligand 21-Overexpressing pancreatic cancer cells. Pathology & Oncology Research, 26(1), 201-208.

Liu, B., Lisberg, A., Salehi-Rad, R., Lee, J. M., Tran, L. M., Krysan, K., ... & Dubinett, S. M. (2020). A33 Phase I Trial of in Situ Vaccination with Autologous CCL21-Modified Dendritic Cells (CCL21-DC) Combined with Pembrolizumab for Advanced NSCLC. Journal of Thoracic Oncology, 15(2), S23.

Liu, M. Z., Chen, S. M., Xu, Y., Kong, Y. G., Deng, Y. Q., Li, F., & Tao, Z. Z. (2020). Increased Expressions and Roles of CC Chemokine Ligand 21 and CC Chemokine Ligand 25 in Chronic Rhinosinusitis with Nasal Polyps. International archives of allergy and immunology, 181(3), 159-169.

Ju, Y., Sun, C., & Wang, X. (2019). Loss of atypical chemokine receptor 4 facilitates C‑C motif chemokine ligand 21‑mediated tumor growth and invasion in nasopharyngeal carcinoma. Experimental and therapeutic medicine, 17(1), 613-620.

Bae, H., Lim, W., Bazer, F. W., Whang, K. Y., & Song, G. (2019). Mitigation of ER-stress and inflammation by chemokine (CC motif) ligand 21 during early pregnancy. Developmental & Comparative Immunology, 94, 73-84.

Hong, C. H., Lin, S. H., & Lee, C. H. (2019). CCL21 induces mTOR-dependent MALAT1 expression, leading to cell migration in cutaneous T-cell lymphoma. in vivo, 33(3), 793-800.

Liu, L., Zhao, L., Yang, Y., Gao, J., Hu, C., Guo, B., & Zhu, B. (2018). Cytotoxic chemotherapy reduces T cell trafficking to the spleen by downregulating the expression of C‑C motif chemokine ligand 21 and C‑C motif chemokine ligand 19. Oncology letters, 16(4), 5013-5019.

Zhong, G., Chen, L., Yin, R., Qu, Y., Bao, Y., Xiao, Q., ... & Tian, H. (2017). Chemokine (C‑C motif) ligand 21/C‑C chemokine receptor type 7 triggers migration and invasion of human lung cancer cells by epithelial‑mesenchymal transition via the extracellular signal‑regulated kinase signaling pathway. Molecular medicine reports, 15(6), 4100-4108.

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For research use only. Not intended for any clinical use.

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