CCL21

CCL21 (C-C Motif Chemokine Ligand 21) is a Protein Coding gene. Diseases associated with CCL21 include Posterolateral Myocardial Infarction and Thymic Hyperplasia. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity and CCR7 chemokine receptor binding.

Full Name

C-C Motif Chemokine Ligand 21

Function

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4.

Biological Process

Activation of GTPase activity Source: BHF-UCL
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cell chemotaxis Source: UniProtKB
Cell maturation Source: BHF-UCL
Cellular response to chemokine Source: BHF-UCL
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine (C-C motif) ligand 21 signaling pathway Source: BHF-UCL
Chemokine-mediated signaling pathway Source: GO_Central
Dendritic cell chemotaxis Source: BHF-UCL
Dendritic cell dendrite assembly Source: BHF-UCL
Eosinophil chemotaxis Source: GO_Central
Establishment of T cell polarity Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: UniProtKB
Immune response Source: ProtInc
Immunological synapse formation Source: BHF-UCL
Inflammatory response Source: GO_Central
Lilling of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Mesangial cell-matrix adhesion Source: BHF-UCL
Monocyte chemotaxis Source: GO_Central
Negative regulation of dendritic cell apoptotic process Source: BHF-UCL
Negative regulation of dendritic cell dendrite assembly Source: BHF-UCL
Negative regulation of leukocyte tethering or rolling Source: UniProtKB
Neutrophil chemotaxis Source: GO_Central
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of cell adhesion mediated by integrin Source: BHF-UCL
Positive regulation of cell-matrix adhesion Source: UniProtKB
Positive regulation of cell motility Source: BHF-UCL
Positive regulation of chemotaxis Source: BHF-UCL
Positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of filopodium assembly Source: BHF-UCL
Positive regulation of glycoprotein biosynthetic process Source: BHF-UCL
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
Positive regulation of JNK cascade Source: BHF-UCL
Positive regulation of myeloid dendritic cell chemotaxis Source: BHF-UCL
Positive regulation of neutrophil chemotaxis Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
Positive regulation of protein kinase activity Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of pseudopodium assembly Source: BHF-UCL
Positive regulation of receptor-mediated endocytosis Source: BHF-UCL
Positive regulation of T cell chemotaxis Source: BHF-UCL
Positive regulation of T cell migration Source: MGI
Release of sequestered calcium ion into cytosol Source: BHF-UCL
Response to prostaglandin E Source: BHF-UCL
Ruffle organization Source: BHF-UCL
T cell costimulation Source: BHF-UCL

Cellular Location

Secreted