Mouse Anti-CCL24 Recombinant Antibody (CBFYM-0935) (CBMAB-M1084-FY)

Name: Mouse Anti-CCL24 Recombinant Antibody (CBFYM-0935)
SKU: CBMAB-M1084-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-0935

Application

ELISA, WB, IP

Immunogen

Recombinant eotaxin-2 of human origin.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

C-C Motif Chemokine Ligand 24

Introduction

CCL11, CCL24, and CCL26 are chemokines involved in the recruitment of eosinophils into tissues and mainly activate CCR3.

Entrez Gene ID

288593

UniProt ID

Q5PPP2

Alternative Names

MPIF2

Function

Chemotactic for resting T-lymphocytes, and eosinophils (PubMed:9104803, PubMed:9365122).
Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes (PubMed:9104803, PubMed:9365122).
Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line (PubMed:9104803, PubMed:9365122).
Binds to CCR3 (PubMed:9104803, PubMed:9365122).

Biological Process

Cell-cell signaling Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytoskeleton organization Source: UniProtKB
Eosinophil chemotaxis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of eosinophil migration Source: Ensembl
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: BHF-UCL
Positive regulation of inflammatory response Source: Ensembl
Regulation of cell shape Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Secreted

PTM

N-glycosylated.

Lim, S. J. (2021). CCL24 Signaling in the Tumor Microenvironment. In Tumor Microenvironment (pp. 91-98). Springer, Cham.

Wang, Y., Wu, X., Geng, M., Ding, J., Lv, K., Du, H., ... & Gao, J. (2021). CCL24 Protects Renal Function by Controlling Inflammation in Podocytes. Disease Markers, 2021.

Segal-Salto, M., Barashi, N., Katav, A., Edelshtein, V., Aharon, A., Hashmueli, S., ... & Mor, A. (2020). A blocking monoclonal antibody to CCL24 alleviates liver fibrosis and inflammation in experimental models of liver damage. JHEP Reports, 2(1), 100064.

Ahmadi, H., Khorramdelazad, H., Hassanshahi, G., Fard, M. A., Ahmadi, Z., Karimabad, M. N., & Mollahosseini, M. (2020). Involvement of eotaxins (CCL11, CCL24, CCL26) in pathogenesis of osteopenia and osteoporosis. Iranian Journal of Public Health, 49(9), 1769.

Deng, Y. K., Ma, J., Wang, Z. C., Long, X. B., Chen, C. L., Feng, Q. M., ... & Liu, Z. (2019, November). Hemokinin‐1 stimulates C‐C motif chemokine ligand 24 production in macrophages to enhance eosinophilic inflammation in nasal polyps. In International forum of allergy & rhinology (Vol. 9, No. 11, pp. 1334-1345).

Lu, K. H., Su, S. C., Lin, C. W., Hsieh, Y. H., Lin, Y. C., Chien, M. H., ... & Yang, S. F. (2018). Melatonin attenuates osteosarcoma cell invasion by suppression of C‐C motif chemokine ligand 24 through inhibition of the c‐Jun N‐terminal kinase pathway. Journal of pineal research, 65(3), e12507.

Negrón-Pérez, V. M., Vargas-Franco, D., & Hansen, P. J. (2017). Role of chemokine (CC motif) ligand 24 in spatial arrangement of the inner cell mass of the bovine embryo. Biology of reproduction, 96(5), 948-959.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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