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Mouse Anti-CCL24 Recombinant Antibody (61016.11) (CBMAB-E0605-FY)

This product is mouse antibody that recognizes CCL24. The antibody 61016.11 can be used for immunoassay techniques such as: ELISA, Neut, WB.
See all CCL24 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
61016.11
Antibody Isotype
IgG1
Application
ELISA, Neut, WB

Basic Information

Immunogen
Purified recombinant human eotaxin 2, expressed in E.coli as immunogen
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-C Motif Chemokine Ligand 24
Introduction
CCL24 (C-C Motif Chemokine Ligand 24) is a Protein Coding gene. Diseases associated with CCL24 include Allergic Asthma and Allergic Hypersensitivity Disease. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and chemokine activity. An important paralog of this gene is CCL13.
Entrez Gene ID
6369
UniProt ID
O00175
Alternative Names
C-C Motif Chemokine Ligand 24; Myeloid Progenitor Inhibitory Factor 2; CK-Beta-6; Eotaxin-2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 24; Eosinophil Chemotactic Protein 2; Chemokine (C-C Motif) Ligand 24
Function
Chemotactic for resting T-lymphocytes, and eosinophils (PubMed:9104803, PubMed:9365122).
Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes (PubMed:9104803, PubMed:9365122).
Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line (PubMed:9104803, PubMed:9365122).
Binds to CCR3 (PubMed:9104803, PubMed:9365122).
Biological Process
Cell-cell signaling Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytoskeleton organization Source: UniProtKB
Eosinophil chemotaxis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of eosinophil migration Source: Ensembl
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: BHF-UCL
Positive regulation of inflammatory response Source: Ensembl
Regulation of cell shape Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
N-glycosylated.

Lim, S. J. (2021). CCL24 Signaling in the Tumor Microenvironment. In Tumor Microenvironment (pp. 91-98). Springer, Cham.

Wang, Y., Wu, X., Geng, M., Ding, J., Lv, K., Du, H., ... & Gao, J. (2021). CCL24 Protects Renal Function by Controlling Inflammation in Podocytes. Disease Markers, 2021.

Segal-Salto, M., Barashi, N., Katav, A., Edelshtein, V., Aharon, A., Hashmueli, S., ... & Mor, A. (2020). A blocking monoclonal antibody to CCL24 alleviates liver fibrosis and inflammation in experimental models of liver damage. JHEP Reports, 2(1), 100064.

Ahmadi, H., Khorramdelazad, H., Hassanshahi, G., Fard, M. A., Ahmadi, Z., Karimabad, M. N., & Mollahosseini, M. (2020). Involvement of eotaxins (CCL11, CCL24, CCL26) in pathogenesis of osteopenia and osteoporosis. Iranian Journal of Public Health, 49(9), 1769.

Deng, Y. K., Ma, J., Wang, Z. C., Long, X. B., Chen, C. L., Feng, Q. M., ... & Liu, Z. (2019, November). Hemokinin‐1 stimulates C‐C motif chemokine ligand 24 production in macrophages to enhance eosinophilic inflammation in nasal polyps. In International forum of allergy & rhinology (Vol. 9, No. 11, pp. 1334-1345).

Lu, K. H., Su, S. C., Lin, C. W., Hsieh, Y. H., Lin, Y. C., Chien, M. H., ... & Yang, S. F. (2018). Melatonin attenuates osteosarcoma cell invasion by suppression of C‐C motif chemokine ligand 24 through inhibition of the c‐Jun N‐terminal kinase pathway. Journal of pineal research, 65(3), e12507.

Negrón-Pérez, V. M., Vargas-Franco, D., & Hansen, P. J. (2017). Role of chemokine (CC motif) ligand 24 in spatial arrangement of the inner cell mass of the bovine embryo. Biology of reproduction, 96(5), 948-959.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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