Human Recombinant CCL24 protein, His Tag (V2LY-0526-LY3850)

Name: Human Recombinant CCL24 protein, His Tag
SKU: V2LY-0526-LY3850
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CCL24 protein, His Tag consist of Amino Acid: 1-119 and predicts a molecular mass of 11.8 kDa.

Molecule Mass

11.8 kDa

Sequence

Amino Acid: 1-119

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

C-C Motif Chemokine Ligand 24

Function

Chemotactic for resting T-lymphocytes, and eosinophils (PubMed:9104803, PubMed:9365122).
Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes (PubMed:9104803, PubMed:9365122).
Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line (PubMed:9104803, PubMed:9365122).
Binds to CCR3 (PubMed:9104803, PubMed:9365122).

Biological Process

Cell-cell signaling Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytoskeleton organization Source: UniProtKB
Eosinophil chemotaxis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of eosinophil migration Source: Ensembl
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: BHF-UCL
Positive regulation of inflammatory response Source: Ensembl
Regulation of cell shape Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Secreted

PTM

N-glycosylated.

Lim, S. J. (2021). CCL24 Signaling in the Tumor Microenvironment. In Tumor Microenvironment (pp. 91-98). Springer, Cham.

Wang, Y., Wu, X., Geng, M., Ding, J., Lv, K., Du, H., ... & Gao, J. (2021). CCL24 Protects Renal Function by Controlling Inflammation in Podocytes. Disease Markers, 2021.

Segal-Salto, M., Barashi, N., Katav, A., Edelshtein, V., Aharon, A., Hashmueli, S., ... & Mor, A. (2020). A blocking monoclonal antibody to CCL24 alleviates liver fibrosis and inflammation in experimental models of liver damage. JHEP Reports, 2(1), 100064.

Ahmadi, H., Khorramdelazad, H., Hassanshahi, G., Fard, M. A., Ahmadi, Z., Karimabad, M. N., & Mollahosseini, M. (2020). Involvement of eotaxins (CCL11, CCL24, CCL26) in pathogenesis of osteopenia and osteoporosis. Iranian Journal of Public Health, 49(9), 1769.

Deng, Y. K., Ma, J., Wang, Z. C., Long, X. B., Chen, C. L., Feng, Q. M., ... & Liu, Z. (2019, November). Hemokinin‐1 stimulates C‐C motif chemokine ligand 24 production in macrophages to enhance eosinophilic inflammation in nasal polyps. In International forum of allergy & rhinology (Vol. 9, No. 11, pp. 1334-1345).

Lu, K. H., Su, S. C., Lin, C. W., Hsieh, Y. H., Lin, Y. C., Chien, M. H., ... & Yang, S. F. (2018). Melatonin attenuates osteosarcoma cell invasion by suppression of C‐C motif chemokine ligand 24 through inhibition of the c‐Jun N‐terminal kinase pathway. Journal of pineal research, 65(3), e12507.

Negrón-Pérez, V. M., Vargas-Franco, D., & Hansen, P. J. (2017). Role of chemokine (CC motif) ligand 24 in spatial arrangement of the inner cell mass of the bovine embryo. Biology of reproduction, 96(5), 948-959.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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