Mouse Anti-CCL26 Recombinant Antibody (CBFYC-0972) (CBMAB-C1028-FY)

Name: Mouse Anti-CCL26 Recombinant Antibody (CBFYC-0972)
SKU: CBMAB-C1028-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-0972

Application

ELISA, WB

Immunogen

E.coli-derived Recombinant Human Eotaxin-3 (CCL26).

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	0.25-0.5 µg/ml
ELISA	1-2 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS

Preservative

None

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

C-C Motif Chemokine Ligand 26

Introduction

CCL26 (C-C Motif Chemokine Ligand 26) is a Protein Coding gene. Diseases associated with CCL26 include Esophagitis and Heart Tumor. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL18.

Entrez Gene ID

10344

UniProt ID

Q9Y258

Alternative Names

C-C Motif Chemokine Ligand 26; Macrophage Inflammatory Protein 4-Alpha; Thymic Stroma Chemokine-1; CC Chemokine IMAC; Eotaxin-3; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 26; Chemokine (C-C Motif) Ligand 26; Small Inducible Cytokine A26; Chemokine N1

Function

Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147).
Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca2+ mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309).
Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis (PubMed:20974991).

Biological Process

Cell-cell signaling Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: CAFA
Chemotaxis Source: ProtInc
Eosinophil chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: CAFA
Neutrophil chemotaxis Source: GO_Central
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of chemotaxis Source: CAFA
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: BHF-UCL
Signal transduction Source: ProtInc
T cell chemotaxis Source: CAFA

Cellular Location

Secreted

Kawano, M., Iwasaki, T., Itonaga, I., Kubota, Y., Tanaka, K., & Tsumura, H. (2021). Analysis of the signal cross talk via CCL26 in the tumor microenvironment in osteosarcoma. Scientific reports, 11(1), 1-11.

Dong, Z., Cao, L., Guo, L., Hong, Y., Cao, J., & Chen, X. (2020). CCL26 regulates the proportion of CD4+ CD25+ FOXP3+ Tregs and the production of inflammatory factors in peripheral blood mononuclear cells following acute ischemic stroke via the STAT5 pathway. Experimental and Therapeutic Medicine, 20(4), 3343-3351.

Tian, P., Ou, H., Wu, F., Ma, Y., Liu, X., Chen, Q., ... & Zou, H. (2019, March). Interleukin‐4‒induced posttranscriptional gene regulation of CCL26 by the RNA‐binding protein HuR in primary human nasal polyp‒derived epithelial cells. In International forum of allergy & rhinology (Vol. 9, No. 3, pp. 311-321).

Shou, J., Peng, J., Zhao, Z., Huang, X., Li, H., Li, L., ... & Liu, H. (2019). CCL26 and CCR3 are associated with the acute inflammatory response in the CNS in experimental autoimmune encephalomyelitis. Journal of neuroimmunology, 333, 576967.

Alotaibi, D. S. (2017). Lipopolysaccharide Inhibits Interleukin–13-induced Chemokine (CC motif) Ligand 26 in Human Airway Epithelial Cells: Possible Role in Eosinophil Chemotaxis in Allergic Asthma.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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