Human Recombinant CCL26 protein (V2LY-0526-LY2629)

Name: Human Recombinant CCL26 protein
SKU: V2LY-0526-LY2629
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Protein Construction

This product is Human Recombinant CCL26 protein consist of Amino Acid: 1-94 and predicts a molecular mass of 8.4 kDa.

Molecule Mass

8.4 kDa

Sequence

Amino Acid: 1-94

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tirs, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

C-C Motif Chemokine Ligand 26

Function

Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147).
Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca2+ mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309).
Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis (PubMed:20974991).

Biological Process

Cell-cell signaling Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: CAFA
Chemotaxis Source: ProtInc
Eosinophil chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: CAFA
Neutrophil chemotaxis Source: GO_Central
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of chemotaxis Source: CAFA
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: BHF-UCL
Signal transduction Source: ProtInc
T cell chemotaxis Source: CAFA

Cellular Location

Secreted

Kawano, M., Iwasaki, T., Itonaga, I., Kubota, Y., Tanaka, K., & Tsumura, H. (2021). Analysis of the signal cross talk via CCL26 in the tumor microenvironment in osteosarcoma. Scientific reports, 11(1), 1-11.

Dong, Z., Cao, L., Guo, L., Hong, Y., Cao, J., & Chen, X. (2020). CCL26 regulates the proportion of CD4+ CD25+ FOXP3+ Tregs and the production of inflammatory factors in peripheral blood mononuclear cells following acute ischemic stroke via the STAT5 pathway. Experimental and Therapeutic Medicine, 20(4), 3343-3351.

Tian, P., Ou, H., Wu, F., Ma, Y., Liu, X., Chen, Q., ... & Zou, H. (2019, March). Interleukin‐4‒induced posttranscriptional gene regulation of CCL26 by the RNA‐binding protein HuR in primary human nasal polyp‒derived epithelial cells. In International forum of allergy & rhinology (Vol. 9, No. 3, pp. 311-321).

Shou, J., Peng, J., Zhao, Z., Huang, X., Li, H., Li, L., ... & Liu, H. (2019). CCL26 and CCR3 are associated with the acute inflammatory response in the CNS in experimental autoimmune encephalomyelitis. Journal of neuroimmunology, 333, 576967.

Alotaibi, D. S. (2017). Lipopolysaccharide Inhibits Interleukin–13-induced Chemokine (CC motif) Ligand 26 in Human Airway Epithelial Cells: Possible Role in Eosinophil Chemotaxis in Allergic Asthma.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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