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Rat Anti-CCT5 Recombinant Antibody (CBYJT-1078) (CBMAB-T0088-YJ)

Provided herein is a Rat monoclonal antibody, which binds to CCT5 (Chaperonin Containing TCP1 Subunit 5). The antibody can be used for immunoassay techniques, such as GS, IP, WB.
See all CCT5 antibodies

Summary

Host Animal
Rat
Specificity
Human, Mouse, Rat, Rabbit, Cattle
Clone
CBYJT-1078
Antibody Isotype
IgG2a
Application
GS, IP, WB

Basic Information

Specificity
Human, Mouse, Rat, Rabbit, Cattle
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chaperonin Containing TCP1 Subunit 5
Introduction
CCT5 (Chaperonin Containing TCP1 Subunit 5) is a component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex it may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Entrez Gene ID
Human22948
Mouse12465
Rat294864
Rabbit100350572
Cattle533784
UniProt ID
HumanP48643
MouseP80316
RatQ68FQ0
RabbitG1TMS5
CattleF1MWD3
Alternative Names
Chaperonin Containing TCP1 Subunit 5; Chaperonin Containing TCP1, Subunit 5 (Epsilon); TCP-1-Epsilon; CCT-Epsilon; CCTE; T-Complex Protein 1 Subunit Epsilon
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).
The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).
As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).
The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Biological Process
Binding of sperm to zona pellucida Source: Ensembl
Positive regulation of establishment of protein localization to telomere Source: BHF-UCL
Positive regulation of protein localization to Cajal body Source: BHF-UCL
Positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Protein folding Source: FlyBase
Protein stabilization Source: BHF-UCL
Response to virus Source: UniProtKB
Toxin transport Source: Ensembl
Cellular Location
Cytoplasm; Centrosome
Involvement in disease
Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP): A disease characterized by spastic paraplegia and progressive distal sensory neuropathy leading to mutilating ulcerations of the upper and lower limbs.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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