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Mouse Anti-CCT5 Recombinant Antibody (4E5-4B1) (CBMAB-C6881-LY)

This product is antibody recognizes CCT5. The antibody 4E5-4B1 immunoassay techniques such as: ELISA, ICC/IF, IHC-P, WB.
See all CCT5 antibodies
Published Data
Fig.1 Immunoblot showing Cathepsin L (CTSL) maturation in CCT5 knockdown HeLa cells.
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Fig.2 N17-103Q-GFP aggregation in CCT-depleted ATG16L1+ and ATG16L1− HeLa cells.
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Fig.3 The increase of p62 levels and aggregation after Cct5 depletion in Drosophila is autophagy dependent.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E5-4B1
Antibody Isotype
IgG1
Application
ELISA, ICC/IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chaperonin Containing TCP1 Subunit 5
Introduction
CCT5 (Chaperonin Containing TCP1 Subunit 5) is a Protein Coding gene. Diseases associated with CCT5 include Neuropathy, Hereditary Sensory, With Spastic Paraplegia, Autosomal Recessive and Neuropathy. Among its related pathways are Organelle biogenesis and maintenance and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and G-protein beta-subunit binding.
Entrez Gene ID
22948
UniProt ID
P48643
Alternative Names
Chaperonin Containing TCP1 Subunit 5; Chaperonin Containing TCP1, Subunit 5 (Epsilon); TCP-1-Epsilon; CCT-Epsilon; CCTE; T-Complex Protein 1 Subunit Epsilon;
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).
The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).
As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).
The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Biological Process
Binding of sperm to zona pellucida Source: Ensembl
Positive regulation of establishment of protein localization to telomere Source: BHF-UCL
Positive regulation of protein localization to Cajal body Source: BHF-UCL
Positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Protein folding Source: FlyBase
Protein stabilization Source: BHF-UCL
Response to virus Source: UniProtKB
Toxin transport Source: Ensembl
Cellular Location
Cytoplasm; Centrosome
Involvement in disease
Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP): A disease characterized by spastic paraplegia and progressive distal sensory neuropathy leading to mutilating ulcerations of the upper and lower limbs.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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