CCT5

CCT5 (Chaperonin Containing TCP1 Subunit 5) is a Protein Coding gene. Diseases associated with CCT5 include Neuropathy, Hereditary Sensory, With Spastic Paraplegia, Autosomal Recessive and Neuropathy. Among its related pathways are Organelle biogenesis and maintenance and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and G-protein beta-subunit binding.
Full Name
Chaperonin Containing TCP1 Subunit 5
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).
The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).
As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).
The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Biological Process
Binding of sperm to zona pellucida Source: Ensembl
Positive regulation of establishment of protein localization to telomere Source: BHF-UCL
Positive regulation of protein localization to Cajal body Source: BHF-UCL
Positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Protein folding Source: FlyBase
Protein stabilization Source: BHF-UCL
Response to virus Source: UniProtKB
Toxin transport Source: Ensembl
Cellular Location
Cytoplasm; Centrosome
Involvement in disease
Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP): A disease characterized by spastic paraplegia and progressive distal sensory neuropathy leading to mutilating ulcerations of the upper and lower limbs.
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Anti-CCT5 antibodies

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Mouse Anti-CCT5 Recombinant Antibody (CBXC-0167) (CBMAB-C5080-CQ)

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Target: CCT5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXC-0167
Application*: WB, IP, IF, E
Datasheet SDS

Human CCT5 ELISA Kit (V2LY-0626-LY5311)

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Target: CCT5
Sensitivity: 0.0048 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Rat Anti-CCT5 Recombinant Antibody (PK/29/23/8d) (CBMAB-C9966-LY)

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Target: CCT5
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rabbit, Rat, Cattle
Clone: PK/29/23/8d
Application*: WB, IP
Datasheet SDS

Mouse Anti-CCT5 Recombinant Antibody (CBXC-2973) (CBMAB-C5081-CQ)

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Target: CCT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: CBXC-2973
Application*: WB, IP
Datasheet SDS

Mouse Anti-CCT5 Recombinant Antibody (CBYJT-1079) (CBMAB-T0089-YJ)

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Target: CCT5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat, Mouse
Clone: CBYJT-1079
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CCT5 Recombinant Antibody (CBYJT-1078) (CBMAB-T0088-YJ)

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Target: CCT5
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-1078
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CCT5 Recombinant Antibody (CBYJT-1077) (CBMAB-T0087-YJ)

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Target: CCT5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-1077
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CCT5 Recombinant Antibody (CBYJT-1076) (CBMAB-T0086-YJ)

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Target: CCT5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-1076
Application*: E, IF, IP, WB, P
Datasheet SDS

Mouse Anti-CCT5 Recombinant Antibody (4E5-4B1) (CBMAB-C6881-LY)

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Target: CCT5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 4E5-4B1
Application*: E, IC/IF, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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