Mouse Anti-CD68 Recombinant Antibody (
22D12) (V2LY-0725-LY116)

Name: Mouse Anti-CD68 Recombinant Antibody (22D12)
SKU: V2LY-0725-LY116
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-CD68 Recombinant Antibody (22D12) (V2LY-0725-LY116) in IHC

IHC staining of human tonsil tissue, diluted at 1:200.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

22D12

Application

ELISA, IHC

Immunogen

Synthetic Peptide.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IHC	1:100-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

CD68 Molecule

Entrez Gene ID

968

UniProt ID

P34810

Alternative Names

CD68 Molecule; CD68 Antigen; Scavenger Receptor Class D, Member 1; Macrophage Antigen CD68; GP110; Macrosialin; SCARD1; LAMP4;

Function

Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Biological Process

Aging Source: ARUK-UCL
Autocrine signaling Source: Ensembl
Cellular response to lipopolysaccharide Source: ARUK-UCL
Cellular response to nutrient levels Source: ARUK-UCL
Cellular response to oxidised low-density lipoprotein particle stimulus Source: ARUK-UCL
Establishment of protein localization to organelle Source: GO_Central
Inflammatory response to antigenic stimulus Source: ARUK-UCL
Negative regulation of dendritic cell antigen processing and presentation Source: ARUK-UCL
Neutrophil degranulation Source: Reactome

Cellular Location

Isoform Short: Cell membrane
Isoform Long: Lysosome membrane; Endosome membrane

Topology

Extracellular: 22-319
Helical: 320-344
Cytoplasmic: 345-354

PTM

N- and O-glycosylated.

Song, Y. J., Xu, Y., Zhu, X., Fu, J., Deng, C., Chen, H., ... & Wang, J. (2020). Immune landscape of the tumor microenvironment identifies prognostic gene signature CD4/CD68/CSF1R in osteosarcoma. Frontiers in oncology, 10, 1198.

Neri, M., Frati, A., Turillazzi, E., Cantatore, S., Cipolloni, L., Di Paolo, M., ... & Fineschi, V. (2018). Immunohistochemical evaluation of aquaporin-4 and its correlation with CD68, IBA-1, HIF-1α, GFAP, and CD15 expressions in fatal traumatic brain injury. International journal of molecular sciences, 19(11), 3544.

Caliò, A., Brunelli, M., Segala, D., Pedron, S., Tardanico, R., Remo, A., ... & Martignoni, G. (2018). t (6; 11) renal cell carcinoma: a study of seven cases including two with aggressive behavior, and utility of CD68 (PG-M1) in the differential diagnosis with pure epithelioid PEComa/epithelioid angiomyolipoma. Modern Pathology, 31(3), 474-487.

Wang, L., Zhang, C., Zhang, Z., Han, B., Shen, Z., Li, L., ... & Zhang, Y. (2018). Specific clinical and immune features of CD68 in glioma via 1,024 samples. Cancer management and research, 10, 6409.

Chistiakov, D. A., Killingsworth, M. C., Myasoedova, V. A., Orekhov, A. N., & Bobryshev, Y. V. (2017). CD68/macrosialin: not just a histochemical marker. Laboratory Investigation, 97(1), 4-13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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