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Mouse Anti-CD68 Recombinant Antibody (CBT3455) (V2LY-0625-LY89)


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Tested Data
Mouse Anti-CD68 Recombinant Antibody (CBT3455) (V2LY-0625-LY89) in WB
Mouse Anti-CD68 Recombinant Antibody (CBT3455) (V2LY-0625-LY89) in WB
Mouse Anti-CD68 Recombinant Antibody (CBT3455) (V2LY-0625-LY89) in WB
Mouse Anti-CD68 Recombinant Antibody (CBT3455) (V2LY-0625-LY89) in WB
Mouse Anti-CD68 Recombinant Antibody (CBT3455) (V2LY-0625-LY89) in FC
Mouse Anti-CD68 Recombinant Antibody (CBT3455) (V2LY-0625-LY89) in FC
Mouse Anti-CD68 Recombinant Antibody (CBT3455) (V2LY-0625-LY89) in ELISA
Mouse Anti-CD68 Recombinant Antibody (CBT3455) (V2LY-0625-LY89) in ELISA

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3455
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human CD68 (AA: 42-155) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD68 Molecule
Entrez Gene ID
968
UniProt ID
P34810
Alternative Names
CD68 Molecule; CD68 Antigen; Scavenger Receptor Class D, Member 1; Macrophage Antigen CD68; GP110; Macrosialin; SCARD1; LAMP4;
Function
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Biological Process
Aging Source: ARUK-UCL
Autocrine signaling Source: Ensembl
Cellular response to lipopolysaccharide Source: ARUK-UCL
Cellular response to nutrient levels Source: ARUK-UCL
Cellular response to oxidised low-density lipoprotein particle stimulus Source: ARUK-UCL
Establishment of protein localization to organelle Source: GO_Central
Inflammatory response to antigenic stimulus Source: ARUK-UCL
Negative regulation of dendritic cell antigen processing and presentation Source: ARUK-UCL
Neutrophil degranulation Source: Reactome
Cellular Location
Isoform Short: Cell membrane
Isoform Long: Lysosome membrane; Endosome membrane
Topology
Extracellular: 22-319
Helical: 320-344
Cytoplasmic: 345-354
PTM
N- and O-glycosylated.
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For research use only. Not intended for any clinical use.

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