Mouse Anti-CD7 Recombinant Antibody (CBFYC-1403) (CBMAB-C1461-FY)

Name: Mouse Anti-CD7 Recombinant Antibody (CBFYC-1403)
SKU: CBMAB-C1461-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-1403

Application

WB, IF, IP, ELISA

Immunogen

Amino acids 27-153 mapping near the N-terminus of CD7 of human origin.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

CD7 Molecule

Introduction

CD7 (CD7 Molecule) is a Protein Coding gene. Diseases associated with CD7 include Pityriasis Lichenoides Et Varioliformis Acuta and T-Cell Leukemia. Among its related pathways are Hematopoietic cell lineage and Innate Lymphoid Cell Differentiation Pathways. Gene Ontology (GO) annotations related to this gene include receptor activity.

Entrez Gene ID

924

UniProt ID

P09564

Alternative Names

CD7 Molecule; T-Cell Leukemia Antigen; T-Cell Surface Antigen Leu-9; T-Cell Antigen CD7; CD7 Antigen (P41); P41 Protein;

Biological Process

Adaptive immune response Source: UniProtKB-KW
Immune response Source: UniProtKB
T cell activation Source: UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 26-180
Helical: 181-201
Cytoplasmic: 202-240

Li, S., Wang, X., Yuan, Z., Liu, L., Luo, L., Li, Y., ... & Wang, S. (2021). Eradication of T-ALL Cells by CD7-targeted Universal CAR-T Cells and Initial Test of Ruxolitinib-based CRS Management. Clinical Cancer Research, 27(5), 1242-1246.

Kim, M. Y., Cooper, M. L., Jacobs, M. T., Ritchey, J. K., Hollaway, J., Fehniger, T. A., & DiPersio, J. F. (2021). CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy. JCI insight, 6(16).

Zhang, J., Jain, A., Milhas, S., Williamson, D. J., Mysliwy, J., Lodge, A., ... & Rabbitts, T. H. (2021). An antibody-drug conjugate with intracellular drug release properties showing specific cytotoxicity against CD7-positive cells. Leukemia Research, 108, 106626.

Gomes-Silva, D., Atilla, E., Atilla, P. A., Mo, F., Tashiro, H., Srinivasan, M., ... & Mamonkin, M. (2019). CD7 CAR T cells for the therapy of acute myeloid leukemia. Molecular Therapy, 27(1), 272-280.

You, F., Wang, Y., Jiang, L., Zhu, X., Chen, D., Yuan, L., ... & Yang, L. (2019). A novel CD7 chimeric antigen receptor-modified NK-92MI cell line targeting T-cell acute lymphoblastic leukemia. American journal of cancer research, 9(1), 64.

Mayer, K. E., Mall, S., Yusufi, N., Gosmann, D., Steiger, K., Russelli, L., ... & Krackhardt, A. M. (2018). T-cell functionality testing is highly relevant to developing novel immuno-tracers monitoring T cells in the context of immunotherapies and revealed CD7 as an attractive target. Theranostics, 8(21), 6070.

Gomes-Silva, D., Srinivasan, M., Sharma, S., Lee, C. M., Wagner, D. L., Davis, T. H., ... & Mamonkin, M. (2017). CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies. Blood, The Journal of the American Society of Hematology, 130(3), 285-296.

Yu, Y., Li, J., Zhu, X., Tang, X., Bao, Y., Sun, X., ... & Yang, L. (2017). Humanized CD7 nanobody-based immunotoxins exhibit promising anti-T-cell acute lymphoblastic leukemia potential. International journal of nanomedicine, 12, 1969.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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