Human Recombinant CD7 protein, AF647 Conjugated, His Tag (V2LY-0526-LY2923)

Name: Human Recombinant CD7 protein, AF647 Conjugated, His Tag
SKU: V2LY-0526-LY2923
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CD7 protein, AF647 Conjugated, His Tag consist of Amino Acid: 1-180 and predicts a molecular mass of 19.9 kDa.

Molecule Mass

19.9 kDa

Conjugates

AF647

Sequence

Amino Acid: 1-180

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Twelve months from date of receipt at -20°C to -70°C in lyophilized form and 3 months at -70°C under sterile conditions after reconstitution. Protect from prolonged exposure to light and avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

CD7 Molecule

Alternative Names

CD7 Molecule; T-Cell Leukemia Antigen; T-Cell Surface Antigen Leu-9; T-Cell Antigen CD7; CD7 Antigen (P41); P41 Protein;

Biological Process

Adaptive immune response Source: UniProtKB-KW
Immune response Source: UniProtKB
T cell activation Source: UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 26-180
Helical: 181-201
Cytoplasmic: 202-240

Li, S., Wang, X., Yuan, Z., Liu, L., Luo, L., Li, Y., ... & Wang, S. (2021). Eradication of T-ALL Cells by CD7-targeted Universal CAR-T Cells and Initial Test of Ruxolitinib-based CRS Management. Clinical Cancer Research, 27(5), 1242-1246.

Kim, M. Y., Cooper, M. L., Jacobs, M. T., Ritchey, J. K., Hollaway, J., Fehniger, T. A., & DiPersio, J. F. (2021). CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy. JCI insight, 6(16).

Zhang, J., Jain, A., Milhas, S., Williamson, D. J., Mysliwy, J., Lodge, A., ... & Rabbitts, T. H. (2021). An antibody-drug conjugate with intracellular drug release properties showing specific cytotoxicity against CD7-positive cells. Leukemia Research, 108, 106626.

Gomes-Silva, D., Atilla, E., Atilla, P. A., Mo, F., Tashiro, H., Srinivasan, M., ... & Mamonkin, M. (2019). CD7 CAR T cells for the therapy of acute myeloid leukemia. Molecular Therapy, 27(1), 272-280.

You, F., Wang, Y., Jiang, L., Zhu, X., Chen, D., Yuan, L., ... & Yang, L. (2019). A novel CD7 chimeric antigen receptor-modified NK-92MI cell line targeting T-cell acute lymphoblastic leukemia. American journal of cancer research, 9(1), 64.

Mayer, K. E., Mall, S., Yusufi, N., Gosmann, D., Steiger, K., Russelli, L., ... & Krackhardt, A. M. (2018). T-cell functionality testing is highly relevant to developing novel immuno-tracers monitoring T cells in the context of immunotherapies and revealed CD7 as an attractive target. Theranostics, 8(21), 6070.

Gomes-Silva, D., Srinivasan, M., Sharma, S., Lee, C. M., Wagner, D. L., Davis, T. H., ... & Mamonkin, M. (2017). CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies. Blood, The Journal of the American Society of Hematology, 130(3), 285-296.

Yu, Y., Li, J., Zhu, X., Tang, X., Bao, Y., Sun, X., ... & Yang, L. (2017). Humanized CD7 nanobody-based immunotoxins exhibit promising anti-T-cell acute lymphoblastic leukemia potential. International journal of nanomedicine, 12, 1969.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant CD7 protein, ECD, His Tag (CAT#: V2LY-0526-LY1448)

Human Recombinant CD7 protein, AF488 Conjugated, His Tag (CAT#: V2LY-0526-LY2922)

Human Recombinant CD7 protein, APC Conjugated, His Tag (CAT#: V2LY-0526-LY2924)

Human Recombinant CD7 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY2925)

Human Recombinant CD7 protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2926)

Human Recombinant CD7 protein, His Tag (CAT#: V2LY-0526-LY2927)

Human Recombinant CD7 protein, PE Conjugated, His Tag (CAT#: V2LY-0526-LY2928)

Mouse Recombinant CD7 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY8059)

Mouse Recombinant CD7 protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY8060)

Mouse Recombinant CD7 protein, His Tag (CAT#: V2LY-0526-LY8061)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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