Mouse Anti-CD7 Recombinant Antibody (CBT2232) (V2LY-0625-LY5)

Name: Mouse Anti-CD7 Recombinant Antibody (CBT2232)
SKU: V2LY-0625-LY5
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-CD7 Recombinant Antibody (CBT2232) (V2LY-0625-LY5) in WB

Mouse Anti-CD7 Recombinant Antibody (CBT2232) (V2LY-0625-LY5) in IHC

Mouse Anti-CD7 Recombinant Antibody (CBT2232) (V2LY-0625-LY5) in ELISA

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT2232

Application

IHC, FC

Immunogen

Purified recombinant fragment of human CD7 (AA: 72-175) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

CD7 Molecule

Entrez Gene ID

924

UniProt ID

P09564

Alternative Names

CD7 Molecule; T-Cell Leukemia Antigen; T-Cell Surface Antigen Leu-9; T-Cell Antigen CD7; CD7 Antigen (P41); P41 Protein;

Biological Process

Adaptive immune response Source: UniProtKB-KW
Immune response Source: UniProtKB
T cell activation Source: UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 26-180
Helical: 181-201
Cytoplasmic: 202-240

Li, S., Wang, X., Yuan, Z., Liu, L., Luo, L., Li, Y., ... & Wang, S. (2021). Eradication of T-ALL Cells by CD7-targeted Universal CAR-T Cells and Initial Test of Ruxolitinib-based CRS Management. Clinical Cancer Research, 27(5), 1242-1246.

Kim, M. Y., Cooper, M. L., Jacobs, M. T., Ritchey, J. K., Hollaway, J., Fehniger, T. A., & DiPersio, J. F. (2021). CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy. JCI insight, 6(16).

Zhang, J., Jain, A., Milhas, S., Williamson, D. J., Mysliwy, J., Lodge, A., ... & Rabbitts, T. H. (2021). An antibody-drug conjugate with intracellular drug release properties showing specific cytotoxicity against CD7-positive cells. Leukemia Research, 108, 106626.

Gomes-Silva, D., Atilla, E., Atilla, P. A., Mo, F., Tashiro, H., Srinivasan, M., ... & Mamonkin, M. (2019). CD7 CAR T cells for the therapy of acute myeloid leukemia. Molecular Therapy, 27(1), 272-280.

You, F., Wang, Y., Jiang, L., Zhu, X., Chen, D., Yuan, L., ... & Yang, L. (2019). A novel CD7 chimeric antigen receptor-modified NK-92MI cell line targeting T-cell acute lymphoblastic leukemia. American journal of cancer research, 9(1), 64.

Mayer, K. E., Mall, S., Yusufi, N., Gosmann, D., Steiger, K., Russelli, L., ... & Krackhardt, A. M. (2018). T-cell functionality testing is highly relevant to developing novel immuno-tracers monitoring T cells in the context of immunotherapies and revealed CD7 as an attractive target. Theranostics, 8(21), 6070.

Gomes-Silva, D., Srinivasan, M., Sharma, S., Lee, C. M., Wagner, D. L., Davis, T. H., ... & Mamonkin, M. (2017). CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies. Blood, The Journal of the American Society of Hematology, 130(3), 285-296.

Yu, Y., Li, J., Zhu, X., Tang, X., Bao, Y., Sun, X., ... & Yang, L. (2017). Humanized CD7 nanobody-based immunotoxins exhibit promising anti-T-cell acute lymphoblastic leukemia potential. International journal of nanomedicine, 12, 1969.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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