Mouse Anti-CD70 Recombinant Antibody (AG39) (V2LY-0524-LY114)

Name: Mouse Anti-CD70 Recombinant Antibody (AG39)
SKU: V2LY-0524-LY114
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

AG39

Application

Blocking, ELISA, FC, IF

Immunogen

Recombinant mouse CD70 (extracellular domain, aa residues 41-195)

Host Species

Mouse

Specificity

Mouse

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

< 1.0 EU/mg as determined by the LAL method

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

5 mg/ml

Purity

>95% by SDS Page

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

CD70 Molecule

Entrez Gene ID

21948

UniProt ID

O55237

Alternative Names

CD70 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD70 Antigen; CD27 Ligand; CD27LG; TNFSF7; CD27-L;

Function

Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

Biological Process

B cell mediated immunity Source: UniProtKB
B cell proliferation Source: UniProtKB
Cell-cell signaling Source: ProtInc
Extrinsic apoptotic signaling pathway Source: BHF-UCL
Positive regulation of T cell proliferation Source: GO_Central
Signal transduction Source: ProtInc
T cell mediated immunity Source: UniProtKB
Tumor necrosis factor-mediated signaling pathway Source: Reactome

Cellular Location

Membrane

Involvement in disease

Lymphoproliferative syndrome 3 (LPFS3): An autosomal recessive, early-onset immunologic disorder characterized by increased susceptibility to Epstein-Barr virus infection in B cells, abnormal B-cell proliferation and increased susceptibility to B-cell malignancies, including Hodgkin lymphoma. Patients usually have lymphadenopathy and hypogammaglobulinemia, and may suffer from recurrent infections.

Topology

Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-193

Liu, W., Maben, Z., Wang, C., Lindquist, K. C., Li, M., Rayannavar, V., ... & Chaparro-Riggers, J. (2021). Structural delineation and phase-dependent activation of the costimulatory CD27: CD70 complex. Journal of Biological Chemistry, 297(4).

Abolhassani, H. (2021). Specific Immune Response and Cytokine Production in CD70 Deficiency. Frontiers in Pediatrics, 9, 254.

Zhang, X., Wang, Y., Zhang, D., Li, H., Zhou, Z., & Yang, R. (2020). CD70‐silenced dendritic cells induce immune tolerance in immune thrombocytopenia patients. British Journal of Haematology, 191(3), 466-475.

Tran-Nguyen, T. K., Xue, J., Feghali-Bostwick, C., Sciurba, F. C., Kass, D. J., & Duncan, S. R. (2020). CD70 activation decreases pulmonary fibroblast production of extracellular matrix proteins. American journal of respiratory cell and molecular biology, 63(2), 255-265.

Riether, C., Pabst, T., Höpner, S., Bacher, U., Hinterbrandner, M., Banz, Y., ... & Ochsenbein, A. F. (2020). Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents. Nature medicine, 26(9), 1459-1467.

Oba, T., Hoki, T., Yamauchi, T., Keler, T., Marsh, H. C., Cao, X., & Ito, F. (2020). A critical role of CD40 and CD70 signaling in conventional type 1 dendritic cells in expansion and antitumor efficacy of adoptively transferred tumor-specific T cells. The Journal of Immunology, 205(7), 1867-1877.

Hornero, R. A., Georgiadis, C., Hua, P., Trzupek, D., He, L. Z., Qasim, W., ... & Hester, J. (2020). CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells. Communications biology, 3(1), 1-17.

Bayat, P., Taghdisi, S. M., Rafatpanah, H., Abnous, K., & Ramezani, M. (2019). In vitro selection of CD70 binding aptamer and its application in a biosensor design for sensitive detection of SKOV-3 ovarian cells. Talanta, 194, 399-405.

Dhaeze, T., Tremblay, L., Lachance, C., Peelen, E., Zandee, S., Grasmuck, C., ... & Prat, A. (2019). CD70 defines a subset of proinflammatory and CNS-pathogenic TH 1/TH 17 lymphocytes and is overexpressed in multiple sclerosis. Cellular & molecular immunology, 16(7), 652-665.

O’Neill, R. E., Du, W., Mohammadpour, H., Alqassim, E., Qiu, J., Chen, G., ... & Cao, X. (2017). T Cell–Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses. The Journal of Immunology, 199(10), 3700-3710.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

CD70 Matched Antibody Pair (234) (CAT#: APMAB-234LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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