Sign in or Register

Keywords Search | Target Search

CD70

CD70 (CD70 Molecule) is a Protein Coding gene. Diseases associated with CD70 include Acute Myocarditis and Lymphoproliferative Syndrome 2. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and protease binding.

Full Name

CD70 Molecule

Function

Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

Biological Process

B cell mediated immunity Source: UniProtKB
B cell proliferation Source: UniProtKB
Cell-cell signaling Source: ProtInc
Extrinsic apoptotic signaling pathway Source: BHF-UCL
Positive regulation of T cell proliferation Source: GO_Central
Signal transduction Source: ProtInc
T cell mediated immunity Source: UniProtKB
Tumor necrosis factor-mediated signaling pathway Source: Reactome

Cellular Location

Membrane

Involvement in disease

Lymphoproliferative syndrome 3 (LPFS3): An autosomal recessive, early-onset immunologic disorder characterized by increased susceptibility to Epstein-Barr virus infection in B cells, abnormal B-cell proliferation and increased susceptibility to B-cell malignancies, including Hodgkin lymphoma. Patients usually have lymphadenopathy and hypogammaglobulinemia, and may suffer from recurrent infections.

Topology

Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-193

Anti-CD70 antibodies

Mouse Anti-CD70 Recombinant Antibody (CBXC-0260) (CBMAB-C4887-CQ)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0260

Application*: IH

Mouse Anti-CD70 Recombinant Antibody (BU69) (CBMAB-C2438-CQ)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: BU69

Application*: F, IC, C, IP

Mouse Anti-CD70 Recombinant Antibody (Ki-24) (CBMAB-C2172-CQ)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human

Clone: Ki-24

Application*: F

Human Anti-CD70 Recombinant Antibody (CBXC-0792) (CBMAB-C1906-CQ)

SDS

Target: CD70

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0792

Application*: F

Mouse Anti-CD70 Recombinant Antibody (TNFS7/1026) (CBMAB-C1146-CQ)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: TNFS7/1026

Application*: F, IP, C, IF

Mouse Anti-CD70 Recombinant Antibody (CBFYC-1413) (CBMAB-C1471-FY)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1413

Application*: F, IH

Rat Anti-CD70 Recombinant Antibody (CBFYC-1412) (CBMAB-C1470-FY)

SDS

Target: CD70

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBFYC-1412

Application*: E, N

Rat Anti-CD70 Recombinant Antibody (CBFYC-1411) (CBMAB-C1469-FY)

SDS

Target: CD70

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBFYC-1411

Application*: F, IP

Rabbit Anti-CD70 Recombinant Antibody (EG547) (CBMAB-EN657-LY)

SDS

Target: CD70

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG547

Application*: WB: 1:500~1:1000 ELISA: 1:40000

Rat Anti-CD70 Recombinant Antibody (TAN1-7) (CBMAB-AP1247LY)

SDS

Target: CD70

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: TAN1-7

Application*: ELISA, FA, FC, IF

Mouse Anti-CD70 Recombinant Antibody (CLB-2F2) (CBMAB-C10586-LY)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CLB-2F2

Application*: F

Rat Anti-CD70 Recombinant Antibody (MAB0825) (CBMAB-C10587-LY)

SDS

Target: CD70

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: MAB0825

Application*: B, F

Rat Anti-CD70 Recombinant Antibody (RM0196-9G24) (CBMAB-C10588-LY)

SDS

Target: CD70

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: RM0196-9G24

Application*: E, N

Mouse Anti-CD70 Recombinant Antibody (13H190) (CBMAB-C1899-CN)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 13H190

Application*: FC, IF

Recombinant Rat Anti-CD70 Recombinant Antibody (TAN 1-7) (CBMAB-XB0194-YC)

SDS

Target: CD70

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: TAN 1-7

Application*: E, F, IF, FN

Mouse Anti-CD70 Recombinant Antibody (CBYY-C1562) (CBMAB-C3000-YY)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-C1562

Application*: F

Mouse Anti-CD70 Recombinant Antibody (CBYY-C1561) (CBMAB-C2999-YY)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-C1561

Application*: E, IC, WB

Mouse Anti-CD70 Recombinant Antibody (CBYY-C0626) (CBMAB-C1914-YY)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C0626

Application*: E, F, IC, IH

Mouse Anti-CD70 Recombinant Antibody (832614) (CBMAB-C8965-LY)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 832614

Application*: F

Mouse Anti-CD70 Recombinant Antibody (7H76) (CBMAB-C8855-LY)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 7H76

Application*: E, C, WB

Mouse Anti-CD70 Recombinant Antibody (7H173) (CBMAB-C8792-LY)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 7H173

Application*: E, F, IC, IH

Rat Anti-CD70 Recombinant Antibody (14L233) (CBMAB-C3128-LY)

SDS

Target: CD70

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 14L233

Application*: E, N

Rat Anti-CD70 Recombinant Antibody (14L232) (CBMAB-C3127-LY)

SDS

Target: CD70

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: 14L232

Application*: F, IP

Mouse Anti-CD70 Recombinant Antibody (10B1934) (CBMAB-C2144-LY)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10B1934

Application*: F, IH

Mouse Anti-CD70 Recombinant Antibody (301731) (CBMAB-C0929-LY)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 301731

Application*: WB, IC

Rat Anti-CD70 Recombinant Antibody (118510) (CBMAB-C0221-LY)

SDS

Target: CD70

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 118510

Application*: N, EC

Mouse Anti-CD70 Recombinant Antibody (113-16) (CBMAB-C0207-LY)

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 113-16

Application*: F

Rat Anti-CD70 Recombinant Antibody (FR70) (CBMAB-0996-LY)

SDS

Target: CD70

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: FR70

Application*: B, F

CD70 Matched Antibody Pair (234) (APMAB-234LY)

SDS

Target: CD70

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

Go to
Compare