CD70 Matched Antibody Pair (234) (APMAB-234LY)

Name: CD70 Matched Antibody Pair (234)
SKU: APMAB-234LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-CD70 monoclonal, IgG1 antibody, 100 ug

Detection Antibody

Anti-CD70 Biotinylated mouse monoclonal, IgG1 antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

CD70 (CD70 Molecule) is a Protein Coding gene. Diseases associated with CD70 include Acute Myocarditis and Lymphoproliferative Syndrome 2. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and protease binding.

Alternative Names

CD70 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD70 Antigen; CD27 Ligand; CD27LG; TNFSF7; CD27-L;

Entrez Gene ID

970

UniProt ID

P32970

More Infomation

Liu, W., Maben, Z., Wang, C., Lindquist, K. C., Li, M., Rayannavar, V., ... & Chaparro-Riggers, J. (2021). Structural delineation and phase-dependent activation of the costimulatory CD27: CD70 complex. Journal of Biological Chemistry, 297(4).

Abolhassani, H. (2021). Specific Immune Response and Cytokine Production in CD70 Deficiency. Frontiers in Pediatrics, 9, 254.

Zhang, X., Wang, Y., Zhang, D., Li, H., Zhou, Z., & Yang, R. (2020). CD70‐silenced dendritic cells induce immune tolerance in immune thrombocytopenia patients. British Journal of Haematology, 191(3), 466-475.

Tran-Nguyen, T. K., Xue, J., Feghali-Bostwick, C., Sciurba, F. C., Kass, D. J., & Duncan, S. R. (2020). CD70 activation decreases pulmonary fibroblast production of extracellular matrix proteins. American journal of respiratory cell and molecular biology, 63(2), 255-265.

Riether, C., Pabst, T., Höpner, S., Bacher, U., Hinterbrandner, M., Banz, Y., ... & Ochsenbein, A. F. (2020). Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents. Nature medicine, 26(9), 1459-1467.

Oba, T., Hoki, T., Yamauchi, T., Keler, T., Marsh, H. C., Cao, X., & Ito, F. (2020). A critical role of CD40 and CD70 signaling in conventional type 1 dendritic cells in expansion and antitumor efficacy of adoptively transferred tumor-specific T cells. The Journal of Immunology, 205(7), 1867-1877.

Hornero, R. A., Georgiadis, C., Hua, P., Trzupek, D., He, L. Z., Qasim, W., ... & Hester, J. (2020). CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells. Communications biology, 3(1), 1-17.

Bayat, P., Taghdisi, S. M., Rafatpanah, H., Abnous, K., & Ramezani, M. (2019). In vitro selection of CD70 binding aptamer and its application in a biosensor design for sensitive detection of SKOV-3 ovarian cells. Talanta, 194, 399-405.

Dhaeze, T., Tremblay, L., Lachance, C., Peelen, E., Zandee, S., Grasmuck, C., ... & Prat, A. (2019). CD70 defines a subset of proinflammatory and CNS-pathogenic TH 1/TH 17 lymphocytes and is overexpressed in multiple sclerosis. Cellular & molecular immunology, 16(7), 652-665.

O’Neill, R. E., Du, W., Mohammadpour, H., Alqassim, E., Qiu, J., Chen, G., ... & Cao, X. (2017). T Cell–Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses. The Journal of Immunology, 199(10), 3700-3710.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant CD70 protein, ECD, His Tag (CAT#: V2LY-0526-LY1449)

Human Recombinant CD70 protein, ECD, AF647 Conjugated, His Tag (CAT#: V2LY-0526-LY2929)

Human Recombinant CD70 protein, Trimer, ECD, APC Conjugated, His Tag (CAT#: V2LY-0526-LY2930)

Human Recombinant CD70 protein, ECD, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY2931)

Human Recombinant CD70 protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY2932)

Human Recombinant CD70 protein, hFc Tag (CAT#: V2LY-0526-LY2933)

Human Recombinant CD70 protein, hFc Tag-1 (CAT#: V2LY-0526-LY2934)

Human Recombinant CD70 protein, hFc Tag-2 (CAT#: V2LY-0526-LY2935)

Human Recombinant CD70 protein, Fc Tag (CAT#: V2LY-0526-LY2936)

Human Recombinant CD70 protein, rFc Tag (CAT#: V2LY-0526-LY2937)

Related Products

Human Recombinant CD70 protein, hFc Tag-1 (CAT#: V2LY-0526-LY2934)

Human Recombinant CD70 protein, ECD, AF647 Conjugated, His Tag (CAT#: V2LY-0526-LY2929)

Rat Recombinant CD70 protein, hFc Tag (CAT#: V2LY-0526-LY9266)

Rat Anti-CD70 Recombinant Antibody (AG38) (CAT#: V2LY-0524-LY113)

Human Recombinant CD70 protein, ECD, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY2931)

Mouse Recombinant CD70 protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY8062)

Rat Anti-CD70 Recombinant Antibody (CBFYC-1412) (CAT#: CBMAB-C1470-FY)

Rat Recombinant CD70 protein, His Tag (CAT#: V2LY-0526-LY9267)

Mouse Recombinant CD70 protein, ECD, His Tag (CAT#: V2LY-0526-LY8063)

Mouse Recombinant CD70 protein, Fc Tag-1 (CAT#: V2LY-0526-LY8066)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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