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CD70 Matched Antibody Pair (234) (APMAB-234LY)

This antibody pair set can be used for detecting and quantifying protein level of human CD70.
See all CD70 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-CD70 monoclonal, IgG1 antibody, 100 ug
Detection Antibody
Anti-CD70 Biotinylated mouse monoclonal, IgG1 antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
CD70 (CD70 Molecule) is a Protein Coding gene. Diseases associated with CD70 include Acute Myocarditis and Lymphoproliferative Syndrome 2. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and protease binding.
Alternative Names
CD70 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD70 Antigen; CD27 Ligand; CD27LG; TNFSF7; CD27-L;
Entrez Gene ID
970
UniProt ID
P32970

Liu, W., Maben, Z., Wang, C., Lindquist, K. C., Li, M., Rayannavar, V., ... & Chaparro-Riggers, J. (2021). Structural delineation and phase-dependent activation of the costimulatory CD27: CD70 complex. Journal of Biological Chemistry, 297(4).

Abolhassani, H. (2021). Specific Immune Response and Cytokine Production in CD70 Deficiency. Frontiers in Pediatrics, 9, 254.

Zhang, X., Wang, Y., Zhang, D., Li, H., Zhou, Z., & Yang, R. (2020). CD70‐silenced dendritic cells induce immune tolerance in immune thrombocytopenia patients. British Journal of Haematology, 191(3), 466-475.

Tran-Nguyen, T. K., Xue, J., Feghali-Bostwick, C., Sciurba, F. C., Kass, D. J., & Duncan, S. R. (2020). CD70 activation decreases pulmonary fibroblast production of extracellular matrix proteins. American journal of respiratory cell and molecular biology, 63(2), 255-265.

Riether, C., Pabst, T., Höpner, S., Bacher, U., Hinterbrandner, M., Banz, Y., ... & Ochsenbein, A. F. (2020). Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents. Nature medicine, 26(9), 1459-1467.

Oba, T., Hoki, T., Yamauchi, T., Keler, T., Marsh, H. C., Cao, X., & Ito, F. (2020). A critical role of CD40 and CD70 signaling in conventional type 1 dendritic cells in expansion and antitumor efficacy of adoptively transferred tumor-specific T cells. The Journal of Immunology, 205(7), 1867-1877.

Hornero, R. A., Georgiadis, C., Hua, P., Trzupek, D., He, L. Z., Qasim, W., ... & Hester, J. (2020). CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells. Communications biology, 3(1), 1-17.

Bayat, P., Taghdisi, S. M., Rafatpanah, H., Abnous, K., & Ramezani, M. (2019). In vitro selection of CD70 binding aptamer and its application in a biosensor design for sensitive detection of SKOV-3 ovarian cells. Talanta, 194, 399-405.

Dhaeze, T., Tremblay, L., Lachance, C., Peelen, E., Zandee, S., Grasmuck, C., ... & Prat, A. (2019). CD70 defines a subset of proinflammatory and CNS-pathogenic TH 1/TH 17 lymphocytes and is overexpressed in multiple sclerosis. Cellular & molecular immunology, 16(7), 652-665.

O’Neill, R. E., Du, W., Mohammadpour, H., Alqassim, E., Qiu, J., Chen, G., ... & Cao, X. (2017). T Cell–Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses. The Journal of Immunology, 199(10), 3700-3710.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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