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Rat Anti-CD96 Recombinant Antibody (6A6) (CBMAB-C1575-YY)

This product is rat antibody that recognizes CD96. The antibody 6A6 can be used for immunoassay techniques such as: FC, FuncS, EIA, WB
See all CD96 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
6A6
Antibody Isotype
IgG2a
Application
FC, FuncS, EIA, WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1 mg/mL
Preservative
PBS, 0.1% BSA
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD96 Molecule
Entrez Gene ID
84544
UniProt ID
Q3U0X8
Alternative Names
Caspase 9; Caspase 9, Apoptosis-Related Cysteine Peptidase; Protein Phosphatase 1, Regulatory Subunit 56; ICE-Like Apoptotic Protease 6; ICE-LAP6; APAF-3; MCH6; Caspase 9, Apoptosis-Related Cysteine Protease; Apoptotic Protease Activating Factor 3;
Function
May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
Biological Process
Cell adhesion Source: ProtInc
Cell-matrix adhesion Source: MGI
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Negative regulation of interferon-gamma production Source: Ensembl
Negative regulation of natural killer cell cytokine production Source: Ensembl
Regulation of immune response Source: Reactome
Response to lipopolysaccharide Source: Ensembl
Cellular Location
Membrane
Involvement in disease
C syndrome (CSYN): The disease is caused by variants affecting the gene represented in this entry. A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint.
A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and low-set, posteriorly rotated ears.
Topology
Extracellular: 22-519
Helical: 520-540
Cytoplasmic: 541-585

Lee, P. S., Chau, B., Barman, I., Bee, C., Jashnani, A., Hogan, J. M., ... & Strop, P. (2021, January). Antibody blockade of CD96 by distinct molecular mechanisms. In Mabs (Vol. 13, No. 1, p. 1979800). Taylor & Francis.

Xie, C., Wang, Z., Li, Y., Wu, F., Xia, H., Lu, Y., ... & Kwok, K. W. (2021). Molecular characterization and expression of CD96 in Nile tilapia (Oreochromis niloticus) in response to different pathogens stimulus. Aquaculture Reports, 20, 100705.

Zhang, H., Liu, Q., Lei, Y., Zhou, J., Jiang, W., Cui, Y., ... & Ke, Z. (2021). Direct interaction between CD155 and CD96 promotes immunosuppression in lung adenocarcinoma. Cellular & molecular immunology, 18(6), 1575-1577.

Maas, R. J., Hoogstad-van Evert, J. S., Van der Meer, J. M., Mekers, V., Rezaeifard, S., Korman, A. J., ... & Dolstra, H. (2020). TIGIT blockade enhances functionality of peritoneal NK cells with altered expression of DNAM-1/TIGIT/CD96 checkpoint molecules in ovarian cancer. Oncoimmunology, 9(1), 1843247.

Liu, F., Huang, J., He, F., Ma, X., Fan, F., Meng, M., ... & Zhang, L. (2020). CD96, a new immune checkpoint, correlates with immune profile and clinical outcome of glioma. Scientific reports, 10(1), 1-10.

Chiang, E. Y., de Almeida, P. E., de Almeida Nagata, D. E., Bowles, K. H., Du, X., Chitre, A. S., ... & Grogan, J. L. (2020). CD96 functions as a co‐stimulatory receptor to enhance CD8+ T cell activation and effector responses. European journal of immunology, 50(6), 891-902.

Sun, H., Huang, Q., Huang, M., Wen, H., Lin, R., Zheng, M., ... & Sun, C. (2019). Human CD96 correlates to natural killer cell exhaustion and predicts the prognosis of human hepatocellular carcinoma. Hepatology, 70(1), 168-183.

Deuss, F. A., Watson, G. M., Fu, Z., Rossjohn, J., & Berry, R. (2019). Structural basis for CD96 immune receptor recognition of nectin-like protein-5, CD155. Structure, 27(2), 219-228.

Georgiev, H., Ravens, I., Papadogianni, G., & Bernhardt, G. (2018). Coming of age: CD96 emerges as modulator of immune responses. Frontiers in immunology, 9, 1072.

Roman Aguilera, A., Lutzky, V. P., Mittal, D., Li, X. Y., Stannard, K., Takeda, K., ... & Smyth, M. J. (2018). CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity. Oncoimmunology, 7(5), e1424677.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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