CD96

CD96 (CD96 Molecule) is a Protein Coding gene. Diseases associated with CD96 include Cat Eye Syndrome and Crouzon Syndrome. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System.
Full Name
CD96 Molecule
Alternative Names
CD96 Molecule; T Cell-Activated Increased Late Expression Protein; Cell Surface Antigen CD96; CD96 Antigen; T Cell Activation, Increased Late Expression; T-Cell Surface Protein Tactile; TACTILE;
Function
May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
Biological Process
Cell adhesion Source: ProtInc
Cell-matrix adhesion Source: MGI
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Negative regulation of interferon-gamma production Source: Ensembl
Negative regulation of natural killer cell cytokine production Source: Ensembl
Regulation of immune response Source: Reactome
Response to lipopolysaccharide Source: Ensembl
Cellular Location
Membrane
Involvement in disease
C syndrome (CSYN): The disease is caused by variants affecting the gene represented in this entry. A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint.
A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and low-set, posteriorly rotated ears.
Topology
Extracellular: 22-519
Helical: 520-540
Cytoplasmic: 541-585
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Anti-CD96 antibodies

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Human Anti-CD96 Recombinant Antibody (CBXC-1268) (CBMAB-C4980-CQ)

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Target: CD96
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1268
Application*: E
Datasheet SDS

Rat Anti-CD96 Recombinant Antibody (3.3) (CBMAB-C0918-LY)

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Target: CD96
Host: Rat
Antibody Isotype: IgG1, λ
Specificity: Mouse
Clone: 3.3
Application*: F, B, in vivo
In Vivo Assay Functional Assay
Datasheet SDS

Rat Anti-CD96 Recombinant Antibody (AG49) (V2LY-0524-LY124)

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Target: CD96
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: AG49
Application*: B, F, In Vivo
In Vivo Assay Functional Assay
Datasheet SDS

Mouse Anti-CD96 Recombinant Antibody (CBT3133) (V2LY-0625-LY1030)

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Target: CD96
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBT3133
Application*: WB, F
Datasheet SDS

Mouse Anti-CD96 Recombinant Antibody (CBT4841) (V2LY-0625-LY1029)

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Target: CD96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4841
Application*: F
Datasheet SDS

CD96 Matched Antibody Pair (240) (APMAB-240LY)

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Target: CD96
Specificity: Human
Datasheet SDS

Rabbit Anti-CD96 Recombinant Antibody (CBR065G) (CBMAB-BT026LY)

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Target: CD96
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBR065G
Application*: E
Datasheet SDS

Rabbit Anti-CD96 Recombinant Antibody (CBFYA-0054) (CBMAB-X0082-FY)

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Target: CD96
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYA-0054
Application*: E
Datasheet SDS

Rabbit Anti-CD96 Recombinant Antibody (CBXC-1661) (CBMAB-C2947-CQ)

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Target: CD96
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXC-1661
Application*: E
Datasheet SDS

Mouse Anti-CD96 Recombinant Antibody (CBYY-C1657) (CBMAB-C3095-YY)

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Target: CD96
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C1657
Application*: E, WB
Datasheet SDS

Mouse Anti-CD96 Recombinant Antibody (CBYY-C0550) (CBMAB-C1667-YY)

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Target: CD96
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C0550
Application*: F, IP, IF
Datasheet SDS

Rat Anti-CD96 Recombinant Antibody (6A6) (CBMAB-C1575-YY)

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Target: CD96
Host: Rat
Antibody Isotype: IgG2a, λ
Specificity: Mouse
Clone: 6A6
Application*: in vivo
In Vivo Assay
Datasheet SDS

Mouse Anti-CD96 Recombinant Antibody (CBFYC-1501) (CBMAB-C1560-FY)

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Target: CD96
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1501
Application*: F
Datasheet SDS

Mouse Anti-CD96 Recombinant Antibody (3H8) (CBMAB-C6353-LY)

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Target: CD96
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3H8
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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