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Rabbit Anti-CDC27 Recombinant Antibody (13G16) (CBMAB-A4293-YC)

Provided herein is a Rabbit monoclonal antibody against Human Cell Division Cycle 27. The antibody can be used for immunoassay techniques, such as IP, WB.
See all CDC27 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey, Mouse, Rat
Clone
13G16
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues near the C-terminal domain of human APC3.
Specificity
Human, Monkey, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
10 mM HEPES, pH 7.5, 150 mM NaCl, 100ug/ml BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
Cell Division Cycle 27
Introduction
CDC27 (Cell Division Cycle 27) is a protein coding gene. Diseases associated with CDC27 include Cervix Carcinoma and Breast Cancer. Among its related pathways are PAK Pathway and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related
Entrez Gene ID
Human996
Mouse217232
Rat360643
Monkey717321
UniProt ID
HumanP30260
MouseA2A6Q5
RatQ4V8A2
MonkeyG7PV30
Alternative Names
Cell Division Cycle 27; Anaphase Promoting Complex Subunit 3; D0S1430E, D17S978E; D0S1430E; D17S978E; CDC27Hs; ANAPC3; H-NUC; APC3;
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Biological Process
Anaphase-promoting complex-dependent catabolic process Source: GO_Central
Cell division Source: GO_Central
Metaphase/anaphase transition of mitotic cell cycle Source: MGI
Positive regulation of mitotic metaphase/anaphase transition Source: GO_Central
Protein K11-linked ubiquitination Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of exit from mitosis Source: Reactome
Regulation of mitotic cell cycle phase transition Source: Reactome
Ubiquitin-dependent protein catabolic process Source: Reactome
Cellular Location
Nucleus; Spindle
PTM
Phosphorylated. Phosphorylation on Ser-426 and Thr-446 oCcurs specifically during mitosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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