CDC27

CDC27 (Cell Division Cycle 27) is a Protein Coding gene. Diseases associated with CDC27 include Cervix Carcinoma and Breast Cancer. Among its related pathways are PAK Pathway and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding.
Full Name
Cell Division Cycle 27
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Biological Process
Anaphase-promoting complex-dependent catabolic process Source: GO_Central
Cell division Source: GO_Central
Metaphase/anaphase transition of mitotic cell cycle Source: MGI
Positive regulation of mitotic metaphase/anaphase transition Source: GO_Central
Protein K11-linked ubiquitination Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of exit from mitosis Source: Reactome
Regulation of mitotic cell cycle phase transition Source: Reactome
Ubiquitin-dependent protein catabolic process Source: Reactome
Cellular Location
Nucleus; Spindle
PTM
Phosphorylated. Phosphorylation on Ser-426 and Thr-446 occurs specifically during mitosis.
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Anti-CDC27 antibodies

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Mouse Anti-CDC27 Recombinant Antibody (CBYY-C0039) (CBMAB-C0105-YY)

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Target: CDC27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0039
Application*: WB, IF, IH, E
Datasheet SDS

Mouse Anti-CDC27 Recombinant Antibody (CBFYC-1515) (CBMAB-C1574-FY)

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Target: CDC27
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-1515
Application*: WB, IF, IP, E, P, F
Datasheet SDS

Mouse Anti-CDC27 Recombinant Antibody (C9093) (CBMAB-C9093-LY)

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Target: CDC27
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Dog
Clone: C9093
Application*: WB, IF, IP, E
Datasheet SDS

Mouse Anti-CDC27 Recombinant Antibody (C7370) (CBMAB-C7370-LY)

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Target: CDC27
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Dog
Clone: C7370
Application*: WB, IF, IP, E
Datasheet SDS

Mouse Anti-CDC27 Recombinant Antibody (C1015) (CBMAB-C1015-LY)

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Target: CDC27
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Dog
Clone: C1015
Application*: WB, IF, IP, E
Datasheet SDS

Mouse Anti-CDC27 Recombinant Antibody (C0617) (CBMAB-C0617-LY)

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Target: CDC27
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Frog, Horse, Dog
Clone: C0617
Application*: WB, IF, IP, P
Datasheet SDS

Rabbit Anti-CDC27 Recombinant Antibody (A4293) (CBMAB-A4293-YC)

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Target: CDC27
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A4293
Application*: WB
Datasheet SDS

Mouse Anti-CDC27 Recombinant Antibody (CBT327) (V2LY-0625-LY3596)

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Target: CDC27
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT327
Application*: WB, P, IF, E
Datasheet SDS

Mouse Anti-CDC27 Recombinant Antibody (CBT3820) (V2LY-0625-LY2469)

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Target: CDC27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3820
Application*: IH
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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