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Mouse Anti-CDH5 Recombinant Antibody (CBFYE-0333) (CBMAB-E0625-FY)

This product is mouse antibody that recognizes CDH5. The antibody CBFYE-0333 can be used for immunoassay techniques such as: WB, IHC-P, IHC-Fr.
See all CDH5 antibodies

Summary

Host Animal
Mouse
Specificity
Cat, Guinea pig, Human
Clone
CBFYE-0333
Antibody Isotype
IgG1
Application
WB, IHC-P, IHC-Fr

Basic Information

Immunogen
Human Endothelium
Specificity
Cat, Guinea pig, Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% BSA
Preservative
0.02% Sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cadherin 5
Introduction
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance.
Entrez Gene ID
Human1003
Cat101084501
Guinea pig100727685
UniProt ID
HumanP33151
CatM3WM81
Guinea pigA0A286Y053
Alternative Names
7B4; CD144
Function
Cadherins are calcium-dependent cell adhesion proteins (By similarity).
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602).
This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity).
It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224).
Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity).
These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120).
Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120).
Biological Process
Adherens junction organization Source: ARUK-UCL
Bicellular tight junction assembly Source: ARUK-UCL
Blood vessel endothelial cell migration Source: ARUK-UCL
Blood vessel maturation Source: Ensembl
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell-cell adhesion Source: ARUK-UCL
Cell-cell adhesion mediated by cadherin Source: ARUK-UCL
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: UniProtKB
Cell morphogenesis Source: GO_Central
Cellular calcium ion homeostasis Source: ARUK-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: ProtInc
Maintenance of blood-brain barrier Source: ARUK-UCL
Multicellular organism development Source: GO_Central
Negative regulation of cell population proliferation Source: Ensembl
Negative regulation of endothelial cell apoptotic process Source: ARUK-UCL
Negative regulation of inflammatory response Source: BHF-UCL
Negative regulation of microtubule polymerization Source: ARUK-UCL
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of BMP signaling pathway Source: ARUK-UCL
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of establishment of endothelial barrier Source: UniProtKB
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of protein-containing complex assembly Source: ARUK-UCL
Positive regulation of protein dephosphorylation Source: ARUK-UCL
Protein localization to bicellular tight junction Source: ARUK-UCL
Regulation of establishment of cell polarity Source: UniProtKB
Regulation of protein phosphorylation Source: ARUK-UCL
Regulation of vascular permeability Source: ARUK-UCL
Transforming growth factor beta receptor signaling pathway Source: UniProtKB
Vasculature development Source: GO_Central
Cellular Location
Cell membrane; Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.
Topology
Extracellular: 48-599
Helical: 600-620
Cytoplasmic: 621-784
PTM
Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity).
O-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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