CDH5

CDH5 (Cadherin 5) is a Protein Coding gene. Diseases associated with CDH5 include Periapical Granuloma and Epithelioid Sarcoma. Among its related pathways are ERK Signaling and RET signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and ion channel binding.

Full Name

Cadherin 5

Function

Cadherins are calcium-dependent cell adhesion proteins (By similarity).
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602).
This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity).
It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224).
Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity).
These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120).
Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120).

Biological Process

Adherens junction organization Source: ARUK-UCL
Bicellular tight junction assembly Source: ARUK-UCL
Blood vessel endothelial cell migration Source: ARUK-UCL
Blood vessel maturation Source: Ensembl
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell-cell adhesion Source: ARUK-UCL
Cell-cell adhesion mediated by cadherin Source: ARUK-UCL
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: UniProtKB
Cell morphogenesis Source: GO_Central
Cellular calcium ion homeostasis Source: ARUK-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: ProtInc
Maintenance of blood-brain barrier Source: ARUK-UCL
Multicellular organism development Source: GO_Central
Negative regulation of cell population proliferation Source: Ensembl
Negative regulation of endothelial cell apoptotic process Source: ARUK-UCL
Negative regulation of inflammatory response Source: BHF-UCL
Negative regulation of microtubule polymerization Source: ARUK-UCL
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of BMP signaling pathway Source: ARUK-UCL
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of establishment of endothelial barrier Source: UniProtKB
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of protein-containing complex assembly Source: ARUK-UCL
Positive regulation of protein dephosphorylation Source: ARUK-UCL
Protein localization to bicellular tight junction Source: ARUK-UCL
Regulation of establishment of cell polarity Source: UniProtKB
Regulation of protein phosphorylation Source: ARUK-UCL
Regulation of vascular permeability Source: ARUK-UCL
Transforming growth factor beta receptor signaling pathway Source: UniProtKB
Vasculature development Source: GO_Central

Cellular Location

Cell membrane; Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.

Topology

Extracellular: 48-599
Helical: 600-620
Cytoplasmic: 621-784

PTM

Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity).
O-glycosylated.

CDH5

Anti-CDH5 antibodies