Mouse Anti-CDHR2 Recombinant Antibody (1D2) (CBMAB-C3816-LY)

Name: Mouse Anti-CDHR2 Recombinant Antibody (1D2)
SKU: CBMAB-C3816-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1D2

Application

ELISA, WB

Immunogen

PCLKC (210 a.a. ~ 318 a.a) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG3, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cadherin Related Family Member 2

Introduction

CDHR2 (Cadherin Related Family Member 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDH15.

Entrez Gene ID

54825

UniProt ID

Q9BYE9

Alternative Names

Cadherin Related Family Member 2; Cadherin-Related Family Member 2; Protocadherin LKC; Protocadherin-24; PCDH24; PCLKC; Protocadherin 24; PC-LKC;

Function

Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409).
May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771).

Biological Process

Cell-cell adhesion Source: GO_Central
Cell-cell adhesion mediated by cadherin Source: UniProtKB
Epithelial cell differentiation Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Intermicrovillar adhesion Source: UniProtKB
Negative regulation of cell growth involved in contact inhibition Source: UniProtKB
Regulation of microvillus length Source: UniProtKB

Cellular Location

Apical cell membrane; Microvillus membrane; Cell junction

Topology

Extracellular: 21-1154
Helical: 1155-1175
Cytoplasmic: 1176-1310

Xia, Z., Huang, M., Zhu, Q., Li, Y., Ma, Q., Wang, Y., ... & Lu, B. (2019). Cadherin Related Family Member 2 Acts As A Tumor Suppressor By Inactivating AKT In Human Hepatocellular Carcinoma. Journal of Cancer, 10(4), 864.

Pinette, J. A., Mao, S., Millis, B. A., Krystofiak, E. S., Faust, J. J., & Tyska, M. J. (2019). Brush border protocadherin CDHR2 promotes the elongation and maximized packing of microvilli in vivo. Molecular biology of the cell, 30(1), 108-118.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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