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Mouse Anti-CDHR2 Recombinant Antibody (1D2) (CBMAB-C3816-LY)

This product is antibody recognizes CDHR2. The antibody 1D2 immunoassay techniques such as: ELISA, WB.
See all CDHR2 antibodies
Published Data
Fig.1 Detection of protocadherin LKC protein in liver.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1D2
Antibody Isotype
IgG3, κ
Application
ELISA, WB

Basic Information

Immunogen
PCLKC (NP_060145, 210 a.a. ~ 318 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: GGMYHNTFTI QCSLPVFLSI SVVDQPDLDP QFVREFYSAS VAEDAAKGTS VLTVEAVDGD KGINDPVIYS ISYSTRPGWF DIGADGVIRV NGSLDREQLL EADEEVQLQ
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cadherin Related Family Member 2
Introduction
CDHR2 (Cadherin Related Family Member 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDH15.
Entrez Gene ID
54825
UniProt ID
Q9BYE9
Alternative Names
Cadherin Related Family Member 2; Cadherin-Related Family Member 2; Protocadherin LKC; Protocadherin-24; PCDH24; PCLKC; Protocadherin 24; PC-LKC;
Function
Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409).
May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771).
Biological Process
Cell-cell adhesion Source: GO_Central
Cell-cell adhesion mediated by cadherin Source: UniProtKB
Epithelial cell differentiation Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Intermicrovillar adhesion Source: UniProtKB
Negative regulation of cell growth involved in contact inhibition Source: UniProtKB
Regulation of microvillus length Source: UniProtKB
Cellular Location
Apical cell membrane; Microvillus membrane; Cell junction
Topology
Extracellular: 21-1154
Helical: 1155-1175
Cytoplasmic: 1176-1310
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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