Human CDHR2 ELISA Kit (V2LY-0626-LY5537)

Name: Human CDHR2 ELISA Kit
SKU: V2LY-0626-LY5537
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0052 ng/mL

Detection Range

0.01-2 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

141.5 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Cadherin Related Family Member 2

Function

Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409).
May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771).

Biological Process

Cell-cell adhesion Source: GO_Central
Cell-cell adhesion mediated by cadherin Source: UniProtKB
Epithelial cell differentiation Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Intermicrovillar adhesion Source: UniProtKB
Negative regulation of cell growth involved in contact inhibition Source: UniProtKB
Regulation of microvillus length Source: UniProtKB

Cellular Location

Apical cell membrane; Microvillus membrane; Cell junction

Topology

Extracellular: 21-1154
Helical: 1155-1175
Cytoplasmic: 1176-1310

Xia, Z., Huang, M., Zhu, Q., Li, Y., Ma, Q., Wang, Y., ... & Lu, B. (2019). Cadherin Related Family Member 2 Acts As A Tumor Suppressor By Inactivating AKT In Human Hepatocellular Carcinoma. Journal of Cancer, 10(4), 864.

Pinette, J. A., Mao, S., Millis, B. A., Krystofiak, E. S., Faust, J. J., & Tyska, M. J. (2019). Brush border protocadherin CDHR2 promotes the elongation and maximized packing of microvilli in vivo. Molecular biology of the cell, 30(1), 108-118.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-CDHR2 Recombinant Antibody (1D2) (CAT#: CBMAB-C3816-LY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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