CDHR2

CDHR2 (Cadherin Related Family Member 2) is a protein coding gene. Gene Ontology annotations related to this gene include calcium ion binding. An important paralog of the gene is PCDH15.

Full Name

Cadherin Related Family Member 2

Function

Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409).
May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771).

Biological Process

Cell-cell adhesion Source: GO_Central
Cell-cell adhesion mediated by cadherin Source: UniProtKB
Epithelial cell differentiation Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Intermicrovillar adhesion Source: UniProtKB
Negative regulation of cell growth involved in contact inhibition Source: UniProtKB
Regulation of microvillus length Source: UniProtKB

Cellular Location

Apical cell membrane; Microvillus membrane; Cell junction

Topology

Extracellular: 21-1154
Helical: 1155-1175
Cytoplasmic: 1176-1310