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Mouse Anti-CDK14 Recombinant Antibody (C-3) (CBMAB-P0168-YC)

Provided herein is a Mouse monoclonal antibody against Human Cyclin Dependent Kinase 14. The antibody can be used for immunoassay techniques, such as WB, IP, IF, IHC-P, ELISA.
See all CDK14 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
C-3
Antibody Isotype
IgG
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cyclin Dependent Kinase 14
Introduction
CDK14 (Cyclin Dependent Kinase 14) is a protein coding gene. Among its related pathways are Transcriptional misregulation in cancer. Gene Ontology annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of the gene is CDK15.
Entrez Gene ID
Human5218
Mouse18647
Rat362316
UniProt ID
HumanO94921
MouseO35495
RatD3ZSZ0
Alternative Names
Cyclin Dependent Kinase 14; Serine/Threonine-Protein Kinase PFTAIRE-1; Cell Division Protein Kinase 14; PFTAIRE Protein Kinase 1; EC 2.7.11.22; PFTK1;
Function
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
Biological Process
Cell division Source: UniProtKB-KW
G2/M transition of mitotic cell cycle Source: UniProtKB
Protein phosphorylation Source: GO_Central
Regulation of canonical Wnt signaling pathway Source: UniProtKB
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Cytoplasm; Nucleus; Cell membrane. Recruited to the cell membrane by CCNY.

Yin, X., Huo, Z., Yan, S., Wang, Z., Yang, T., Wu, H., & Zhang, Z. (2021). MiR-205 Inhibits Sporadic Vestibular Schwannoma Cell Proliferation by Targeting Cyclin-Dependent Kinase 14. World Neurosurgery, 147, e25-e31.

Hisamoto, N., Sakai, Y., Ohta, K., Shimizu, T., Li, C., Hanafusa, H., & Matsumoto, K. (2021). CDK14 Promotes Axon Regeneration by Regulating the Noncanonical Wnt Signaling Pathway in a Kinase-Independent Manner. Journal of Neuroscience, 41(40), 8309-8320.

Wang, Z., Hu, T., Jin, C., Yu, J., Zhu, D., & Liu, J. (2020). The anti-tumor effect of miR-539-3p on colon cancer via regulating cell viability, motility, and nude mouse tumorigenicity with CDK14 inhibition. Journal of Gastrointestinal Oncology, 11(5), 899.

Li, J., Shao, W., & Feng, H. (2019). MiR-542-3p, a microRNA targeting CDK14, suppresses cell proliferation, invasiveness, and tumorigenesis of epithelial ovarian cancer. Biomedicine & Pharmacotherapy, 110, 850-856.

Yan, T. H., Qiu, C., Sun, J., & Li, W. H. (2018). MiR-877-5p suppresses cell growth, migration and invasion by targeting cyclin dependent kinase 14 and predicts prognosis in hepatocellular carcinoma. Eur Rev Med Pharmacol Sci, 22(10), 3038-3046.

Li, Q., Zhou, L., Wang, M., Wang, N., Li, C., Wang, J., & Qi, L. (2018). MicroRNA-613 impedes the proliferation and invasion of glioma cells by targeting cyclin-dependent kinase 14. Biomedicine & Pharmacotherapy, 98, 636-642.

Imawari, Y., Mimoto, R., Hirooka, S., Morikawa, T., Takeyama, H., & Yoshida, K. (2018). Downregulation of dual‐specificity tyrosine‐regulated kinase 2 promotes tumor cell proliferation and invasion by enhancing cyclin‐dependent kinase 14 expression in breast cancer. Cancer science, 109(2), 363-372.

Du, B., Zhang, P., Tan, Z., & Xu, J. (2017). MiR-1202 suppresses hepatocellular carcinoma cells migration and invasion by targeting cyclin dependent kinase 14. Biomedicine & Pharmacotherapy, 96, 1246-1252.

Ou-Yang, J., Huang, L. H., & Sun, X. X. (2017). Cyclin-dependent kinase 14 promotes cell proliferation, migration and invasion in ovarian cancer by inhibiting Wnt signaling pathway. Gynecologic and obstetric investigation, 82(3), 230-239.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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