CDK14

CDK14 (Cyclin Dependent Kinase 14) is a protein coding gene. Among its related pathways are Transcriptional misregulation in cancer. Gene Ontology annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of the gene is CDK15.

Full Name

Cyclin Dependent Kinase 14

Function

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.

Biological Process

Cell division Source: UniProtKB-KW
G2/M transition of mitotic cell cycle Source: UniProtKB
Protein phosphorylation Source: GO_Central
Regulation of canonical Wnt signaling pathway Source: UniProtKB
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Cytoplasm; Nucleus; Cell membrane. Recruited to the cell membrane by CCNY.