Human Recombinant CDK14 protein, GST Tag (V2LY-0526-LY6131)

Name: Human Recombinant CDK14 protein, GST Tag
SKU: V2LY-0526-LY6131
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant CDK14 protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 72 kDa.

Molecule Mass

72 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Cyclin Dependent Kinase 14

Function

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.

Biological Process

Cell division Source: UniProtKB-KW
G2/M transition of mitotic cell cycle Source: UniProtKB
Protein phosphorylation Source: GO_Central
Regulation of canonical Wnt signaling pathway Source: UniProtKB
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Cytoplasm; Nucleus; Cell membrane. Recruited to the cell membrane by CCNY.

Yin, X., Huo, Z., Yan, S., Wang, Z., Yang, T., Wu, H., & Zhang, Z. (2021). MiR-205 Inhibits Sporadic Vestibular Schwannoma Cell Proliferation by Targeting Cyclin-Dependent Kinase 14. World Neurosurgery, 147, e25-e31.

Hisamoto, N., Sakai, Y., Ohta, K., Shimizu, T., Li, C., Hanafusa, H., & Matsumoto, K. (2021). CDK14 Promotes Axon Regeneration by Regulating the Noncanonical Wnt Signaling Pathway in a Kinase-Independent Manner. Journal of Neuroscience, 41(40), 8309-8320.

Wang, Z., Hu, T., Jin, C., Yu, J., Zhu, D., & Liu, J. (2020). The anti-tumor effect of miR-539-3p on colon cancer via regulating cell viability, motility, and nude mouse tumorigenicity with CDK14 inhibition. Journal of Gastrointestinal Oncology, 11(5), 899.

Li, J., Shao, W., & Feng, H. (2019). MiR-542-3p, a microRNA targeting CDK14, suppresses cell proliferation, invasiveness, and tumorigenesis of epithelial ovarian cancer. Biomedicine & Pharmacotherapy, 110, 850-856.

Yan, T. H., Qiu, C., Sun, J., & Li, W. H. (2018). MiR-877-5p suppresses cell growth, migration and invasion by targeting cyclin dependent kinase 14 and predicts prognosis in hepatocellular carcinoma. Eur Rev Med Pharmacol Sci, 22(10), 3038-3046.

Li, Q., Zhou, L., Wang, M., Wang, N., Li, C., Wang, J., & Qi, L. (2018). MicroRNA-613 impedes the proliferation and invasion of glioma cells by targeting cyclin-dependent kinase 14. Biomedicine & Pharmacotherapy, 98, 636-642.

Imawari, Y., Mimoto, R., Hirooka, S., Morikawa, T., Takeyama, H., & Yoshida, K. (2018). Downregulation of dual‐specificity tyrosine‐regulated kinase 2 promotes tumor cell proliferation and invasion by enhancing cyclin‐dependent kinase 14 expression in breast cancer. Cancer science, 109(2), 363-372.

Du, B., Zhang, P., Tan, Z., & Xu, J. (2017). MiR-1202 suppresses hepatocellular carcinoma cells migration and invasion by targeting cyclin dependent kinase 14. Biomedicine & Pharmacotherapy, 96, 1246-1252.

Ou-Yang, J., Huang, L. H., & Sun, X. X. (2017). Cyclin-dependent kinase 14 promotes cell proliferation, migration and invasion in ovarian cancer by inhibiting Wnt signaling pathway. Gynecologic and obstetric investigation, 82(3), 230-239.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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