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Rat Anti-CER1 Recombinant Antibody (CBFYC-1727) (CBMAB-C1789-FY)


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Summary

Host Animal
Rat
Specificity
Human, Mouse
Clone
CBFYC-1727
Antibody Isotype
IgG2a
Application
IHC, WB

Basic Information

Immunogen
Recombinant mouse Cerberus 1 Asp18-Pro272.
Host Species
Rat
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cerberus 1, DAN Family BMP Antagonist
Introduction
This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity.
Entrez Gene ID
12622
UniProt ID
O55233
Alternative Names
Cerl; Cerl1; Cerr1; cer-1
Function
Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).
Biological Process
Anterior/posterior axis specification Source: BHF-UCL
Anterior/posterior pattern specification Source: BHF-UCL
Bone mineralization Source: BHF-UCL
Cell migration involved in gastrulation Source: BHF-UCL
Cellular response to BMP stimulus Source: BHF-UCL
Cellular response to cadmium ion Source: Ensembl
Determination of dorsal identity Source: BHF-UCL
Determination of heart left/right asymmetry Source: GO_Central
Gastrulation Source: BHF-UCL
Growth plate cartilage chondrocyte proliferation Source: BHF-UCL
Negative regulation of activin receptor signaling pathway Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of mesoderm development Source: BHF-UCL
Negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: GO_Central
Nervous system development Source: BHF-UCL
Sequestering of BMP from receptor via BMP binding Source: Reactome
Sequestering of BMP in extracellular matrix Source: BHF-UCL
Signal transduction involved in regulation of gene expression Source: BHF-UCL
Ureteric bud development Source: UniProtKB
Cellular Location
Secreted
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

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