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CER1

This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]

Full Name

Cerberus 1, DAN Family BMP Antagonist

Function

Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).

Biological Process

Anterior/posterior axis specification Source: BHF-UCL
Anterior/posterior pattern specification Source: BHF-UCL
Bone mineralization Source: BHF-UCL
Cell migration involved in gastrulation Source: BHF-UCL
Cellular response to BMP stimulus Source: BHF-UCL
Cellular response to cadmium ion Source: Ensembl
Determination of dorsal identity Source: BHF-UCL
Determination of heart left/right asymmetry Source: GO_Central
Gastrulation Source: BHF-UCL
Growth plate cartilage chondrocyte proliferation Source: BHF-UCL
Negative regulation of activin receptor signaling pathway Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of mesoderm development Source: BHF-UCL
Negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: GO_Central
Nervous system development Source: BHF-UCL
Sequestering of BMP from receptor via BMP binding Source: Reactome
Sequestering of BMP in extracellular matrix Source: BHF-UCL
Signal transduction involved in regulation of gene expression Source: BHF-UCL
Ureteric bud development Source: UniProtKB

Cellular Location

Secreted

PTM

N-glycosylated.

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Anti-CER1 antibodies

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Rabbit Anti-CER1 Recombinant Antibody (CBFYC-1730) (CBMAB-C1792-FY)

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Target: CER1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-1730

Application*: E

Mouse Anti-CER1 Recombinant Antibody (CBT335) (V2LY-0625-LY3588)

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Target: CER1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBT335

Application*: WB, P, IF, E

Mouse Anti-CER1 Recombinant Antibody (CBT336) (V2LY-0625-LY3587)

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Target: CER1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBT336

Application*: WB, E

Mouse Anti-CER1 Recombinant Antibody (CBT4392) (V2LY-0625-LY2382)

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Target: CER1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT4392

Application*: IH

Mouse Anti-CER1 Recombinant Antibody (CBT4730) (V2LY-0625-LY2381)

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Target: CER1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT4730

Application*: WB

CER1 Matched Antibody Pair (263) (APMAB-263LY)

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Target: CER1

Specificity: Human

CER1 Matched Antibody Pair (262) (APMAB-262LY)

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Target: CER1

Specificity: Human

Mouse Anti-CER1 Recombinant Antibody (CBXC-0982) (CBMAB-C1244-CQ)

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Target: CER1

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBXC-0982

Application*: WB, P

Rat Anti-CER1 Recombinant Antibody (CBYY-C1885) (CBMAB-C3323-YY)

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Target: CER1

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYY-C1885

Application*: WB

Mouse Anti-CER1 Recombinant Antibody (CBYY-C1884) (CBMAB-C3322-YY)

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Target: CER1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C1884

Application*: E, WB, IH, IF

Mouse Anti-CER1 Recombinant Antibody (CBYY-C1883) (CBMAB-C3321-YY)

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Target: CER1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-C1883

Application*: IH, WB

Mouse Anti-CER1 Recombinant Antibody (CBFYC-1729) (CBMAB-C1791-FY)

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Target: CER1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: CBFYC-1729

Application*: WB, IP, IF, E

Rat Anti-CER1 Recombinant Antibody (CBFYC-1727) (CBMAB-C1789-FY)

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Target: CER1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBFYC-1727

Application*: IH, WB

Mouse Anti-CER1 Recombinant Antibody (5C6) (CBMAB-C7402-LY)

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Target: CER1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5C6

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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