CER1

This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]

Cerberus 1, DAN Family BMP Antagonist

Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).

Anterior/posterior axis specification Source: BHF-UCL
Anterior/posterior pattern specification Source: BHF-UCL
Bone mineralization Source: BHF-UCL
Cell migration involved in gastrulation Source: BHF-UCL
Cellular response to BMP stimulus Source: BHF-UCL
Cellular response to cadmium ion Source: Ensembl
Determination of dorsal identity Source: BHF-UCL
Determination of heart left/right asymmetry Source: GO_Central
Gastrulation Source: BHF-UCL
Growth plate cartilage chondrocyte proliferation Source: BHF-UCL
Negative regulation of activin receptor signaling pathway Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of mesoderm development Source: BHF-UCL
Negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: GO_Central
Nervous system development Source: BHF-UCL
Sequestering of BMP from receptor via BMP binding Source: Reactome
Sequestering of BMP in extracellular matrix Source: BHF-UCL
Signal transduction involved in regulation of gene expression Source: BHF-UCL
Ureteric bud development Source: UniProtKB

Secreted

N-glycosylated.