Mouse Anti-CGGBP1 Recombinant Antibody (CBXC-0406) (CBMAB-C5856-CQ)

This product is a mouse antibody that recognizes CGGBP1. The antibody CBXC-0406 can be used for immunoassay techniques such as: ELISA, ICC, IHC, WB.
See all CGGBP1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXC-0406

Antibody Isotype

IgG1

Application

ELISA, ICC, IHC, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Preservative

0.09% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 58-168

Target

Full Name

CGG triplet repeat binding protein 1

Introduction

This gene encodes a CGG repeat-binding protein that primarily localizes to the nucleus. CGG trinucleotide repeats are implicated in many disorders as they often act as transcription- and translation-regulatory elements, can produce hairpin structures which cause DNA replication errors, and form regions prone to chromosomal breakage. CGG repeats are also targets for CpG methylation. In addition to its ability to bind CGG repeats and regulate transcription, this gene is believed to play a role in DNA damage repair and telomere protection. In vitro studies indicate this protein does not bind to methylated CpG sequences.

Entrez Gene ID

8545

UniProt ID

Q9UFW8

Alternative Names

CGG Triplet Repeat Binding Protein 1; P20-CGGBP DNA-Binding Protein; 20 KDa CGG-Binding Protein; P20-CGG Binding Protein; CGG-Binding Protein 1; CGGBP; CGG Triplet Repeat-Binding Protein 1; P20-CGGBP;

Function

Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter.

Biological Process

Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of gene expression Source: GO_Central
Regulation of gene expression, epigenetic Source: ARUK-UCL

Cellular Location

Nucleus

References

Yellan, I., Yang, A. W., & Hughes, T. R. (2021). Diverse Eukaryotic CGG-Binding Proteins Produced by Independent Domestications of hAT Transposons. Molecular biology and evolution, 38(5), 2070-2075.

Patel, M., Patel, D., Datta, S., & Singh, U. (2020). CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity. BMC genetics, 21(1), 1-21.

Patel, M., Patel, D., Datta, S., & Singh, U. (2020). An immunochemistry-based screen for chemical inhibitors of DNA-protein interactions and its application to human CGGBP1. BMC cancer, 20(1), 1-14.

Patel, M., Patel, D., Datta, S., & Singh, U. (2020). HDAC inhibitor Givinostat targets DNA-binding of human CGGBP1.

Patel, D., Patel, M., Datta, S., & Singh, U. (2019). CGGBP1 regulates CTCF occupancy at repeats. Epigenetics & chromatin, 12(1), 1-22.

Patel, D., Patel, M., & Singh, U. (2019). CGGBP1 regulates chromatin barrier activity and CTCF occupancy at repeats. bioRxiv, 593137.

Patel, D., Patel, M., Westermark, B., & Singh, U. (2018). Dynamic bimodal changes in CpG and non-CpG methylation genome-wide upon CGGBP1 loss-of-function. BMC research notes, 11(1), 1-7.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-CGGBP1 Recombinant Antibody (1D11)

Mouse Anti-CGGBP1 (AA 58-168) Recombinant Antibody (CBFYC-1790)

Mouse Anti-CGGBP1 Recombinant Antibody (CBWJC-2614)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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