Mouse Anti-CHCHD3 Recombinant Antibody (CBXC-3060) (CBMAB-C5802-CQ)

Name: Mouse Anti-CHCHD3 Recombinant Antibody (CBXC-3060)
SKU: CBMAB-C5802-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXC-3060

Application

WB, IHC

Immunogen

Human recombinant protein fragment corresponding to amino acids 2-227 of human CHCHD3.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IHC	1:150
WB	1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3

Introduction

The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

54927

UniProt ID

Q9NX63

Alternative Names

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3; Mitochondrial Inner Membrane Organizing System 3; Protein Phosphatase 1, Regulatory Subunit 22; MINOS3; Mic19; Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 3, Mitochondrial; Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 3; MICOS Complex Subunit MIC19; PPP1R22;

Function

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180).

Biological Process

Cristae formation Source: UniProtKB
Inner mitochondrial membrane organization Source: UniProtKB
Mitochondrial fusion Source: UniProtKB

Cellular Location

Cytoplasm; Nucleus; Mitochondrion inner membrane; Mitochondrion

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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