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Mouse Anti-CHCHD3 Recombinant Antibody (2A6) (CBMAB-C4627-LY)

This product is antibody recognizes CHCHD3. The antibody 2A6 immunoassay techniques such as: IHC-P, WB.
See all CHCHD3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A6
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3
Introduction
The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Entrez Gene ID
54927
UniProt ID
Q9NX63
Alternative Names
Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3; Mitochondrial Inner Membrane Organizing System 3; Protein Phosphatase 1, Regulatory Subunit 22; MINOS3; Mic19; Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 3, Mitochondrial; Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 3; MICOS Complex Subunit MIC19; PPP1R22;
Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180).
Biological Process
Cristae formation Source: UniProtKB
Inner mitochondrial membrane organization Source: UniProtKB
Mitochondrial fusion Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus; Mitochondrion inner membrane; Mitochondrion
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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