CHCHD3

The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Full Name
Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3
Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180).
Biological Process
Cristae formation Source: UniProtKB
Inner mitochondrial membrane organization Source: UniProtKB
Mitochondrial fusion Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus; Mitochondrion inner membrane; Mitochondrion
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Anti-CHCHD3 antibodies

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Mouse Anti-CHCHD3 Recombinant Antibody (CBXC-3060) (CBMAB-C5802-CQ)

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Target: CHCHD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-3060
Application*: WB, IH
Datasheet SDS

Mouse Anti-CHCHD3 Recombinant Antibody (CBYY-C1958) (CBMAB-C3396-YY)

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Target: CHCHD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1958
Application*: IH, WB
Datasheet SDS

Mouse Anti-CHCHD3 Recombinant Antibody (CBFYC-1806) (CBMAB-C1868-FY)

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Target: CHCHD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYC-1806
Application*: IH, WB
Datasheet SDS

Mouse Anti-CHCHD3 Recombinant Antibody (2A6) (CBMAB-C4627-LY)

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Target: CHCHD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A6
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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