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Rabbit Anti-CHKA Recombinant Antibody (CBWJC-2686) (CBMAB-C3779WJ)

This product is a Rabbit antibody that recognizes CHKA. This antibody CBWJC-2686 can be used for immunoassay techniques such as: WB, IP.
See all CHKA antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
CBWJC-2686
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CHKA
Introduction
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human1119
Monkey710564
UniProt ID
HumanP35790
MonkeyA0A2K5V583
Alternative Names
Choline Kinase Alpha; Ethanolamine Kinase; CHETK-Alpha; CHK; CKI; CK;
Function
Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.
Biological Process
Choline metabolic process Source: Ensembl
Ethanolamine metabolic process Source: Ensembl
Lipid metabolic process Source: ProtInc
Lipid transport Source: ProtInc
Phosphatidylcholine biosynthetic process Source: UniProtKB
Phosphatidylethanolamine biosynthetic process Source: UniProtKB
Response to 3-methylcholanthrene Source: Ensembl
Response to toxic substance Source: Ensembl
Cellular Location
Cytoplasm

Wang, N., Brickute, D., Braga, M., Barnes, C., Lu, H., Allott, L., & Aboagye, E. O. (2021). Novel Non-Congeneric Derivatives of the Choline Kinase Alpha Inhibitor ICL-CCIC-0019. Pharmaceutics, 13(7), 1078.

Zou, Y., Huang, L., Sun, S., Yue, F., Li, Z., Ma, Y., & Ma, H. (2021). Choline Kinase Alpha Promoted Glioma Development by Activating PI3K/AKT Signaling Pathway. Cancer Biotherapy and Radiopharmaceuticals.

Raikundalia, S., Mohamed Sa'dom, S. A. F., Few, L. L., & See Too, W. C. (2021). MicroRNA‑367‑3p induces apoptosis and suppresses migration of MCF‑7 cells by downregulating the expression of human choline kinase α. Oncology letters, 21(3), 1-1.

Mohamed Sa’dom, S. A. F., Raikundalia, S., Shamsuddin, S., See Too, W. C., & Few, L. L. (2021). DNA Methylation of Human Choline Kinase Alpha Promoter-Associated CpG Islands in MCF-7 Cells. Genes, 12(6), 853.

Kong, M., Dong, W., Xu, H., Fan, Z., Miao, X., Guo, Y., ... & Xu, Y. (2021). Choline kinase alpha is a novel transcriptional target of the Brg1 in hepatocyte: implication in liver regeneration. Frontiers in Cell and Developmental Biology, 2197.

Rizzo, A., Satta, A., Garrone, G., Cavalleri, A., Napoli, A., Raspagliesi, F., ... & Bagnoli, M. (2021). Choline kinase alpha impairment overcomes TRAIL resistance in ovarian cancer cells. Journal of Experimental & Clinical Cancer Research, 40(1), 1-13.

Yue, F., Zou, Y., Sun, S., Wang, Z., Huang, L., & Ma, H. (2020). Knockdown of choline kinase α (CHKA) inhibits the proliferation, invasion and migration of human U87MG glioma cells. Xi bao yu fen zi Mian yi xue za zhi= Chinese Journal of Cellular and Molecular Immunology, 36(8), 724-728.

Domizi, P., Malizia, F., Chazarreta-Cifre, L., Diacovich, L., & Banchio, C. (2019). KDM2B regulates choline kinase expression and neuronal differentiation of neuroblastoma cells. Plos one, 14(1), e0210207.

Lin, X. M., Hu, L., Gu, J., Wang, R. Y., Li, L., Tang, J., ... & Chen, L. (2017). Choline kinase α mediates interactions between the epidermal growth factor receptor and mechanistic target of rapamycin complex 2 in hepatocellular carcinoma cells to promote drug resistance and xenograft tumor progression. Gastroenterology, 152(5), 1187-1202.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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