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Mouse Anti-CHL1 Recombinant Antibody (CBYY-C2062) (CBMAB-C3500-YY)

This product is mouse antibody that recognizes CHL1. The antibody CBYY-C2062 can be used for immunoassay techniques such as: ELISA, ELISA(Det)
See all CHL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C2062
Antibody Isotype
IgG1
Application
ELISA, ELISA(Det)

Basic Information

Immunogen
Recombinant Human CHL-1 Protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
cell adhesion molecule with homology to L1CAM (close homolog of L1)
Entrez Gene ID
10752
UniProt ID
O00533
Alternative Names
B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200
Function
Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity).
Biological Process
Axon guidance Source: InterPro
Axon regeneration Source: Ensembl
Cell adhesion Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Cell membrane. Soluble forms produced by cleavage/shedding also exist.
Processed neural cell adhesion molecule L1-like protein: Extracellular matrix
Topology
Extracellular: 25-1082
Helical: 1083-1103
Cytoplasmic: 1104-1208
PTM
Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors (By similarity). Cleaved by BACE1 (By similarity).
N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc) (By similarity).
O-glycosylated.

Chen, Y., Sun, T., Niu, Y., Wang, D., Liu, K., Wang, T., ... & Liu, J. (2021). Cell adhesion molecule L1 like plays a role in the pathogenesis of idiopathic hypogonadotropic hypogonadism. Journal of Endocrinological Investigation, 1-13.

Loers, G., Theis, T., Baixia Hao, H., Kleene, R., Arsha, S., Samuel, N., ... & Schachner, M. (2021). Interplay in neural functions of cell adhesion molecule close homolog of L1 (CHL1) and Programmed Cell Death 6 (PDCD6). FASEB BioAdvances.

Yang, C. R., Ning, L., Zhou, F. H., Sun, Q., Meng, H. P., Han, Z., ... & Zhou, X. F. (2020). Downregulation of adhesion molecule CHL1 in B cells but not T cells of patients with major depression and in the brain of mice with chronic stress. Neurotoxicity research, 38(4), 914-928.

Lin, W. W., Ou, G. Y., Lin, J. Z., Yi, S. J., Yao, W. C., Pan, H. C., & Zhao, W. J. (2020). Neuregulin 1 enhances cell adhesion molecule L1 like expression levels and promotes malignancy in human glioma. Oncology letters, 20(1), 326-336.

Karstens, K. F., Bellon, E., Polonski, A., Wolters-Eisfeld, G., Melling, N., Reeh, M., ... & Tachezy, M. (2020). Expression and serum levels of the neural cell adhesion molecule L1-like protein (CHL1) in gastrointestinal stroma tumors (GIST) and its prognostic power. Oncotarget, 11(13), 1131.

Tang, H., Jiang, L., Zhu, C., Liu, R., Wu, Y., Yan, Q., ... & Guan, X. Y. (2019). Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma. Oncogene, 38(17), 3119-3133.

Zhang, C., Wu, W., Ye, X., Ma, R., Luo, J., Zhu, H., & Chang, X. (2019). Aberrant expression of CHL1 gene and long non-coding RNA CHL1-AS1, CHL1-AS2 in ovarian endometriosis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 236, 177-182.

Guseva, D., Jakovcevski, I., Irintchev, A., Leshchyns’Ka, I., Sytnyk, V., Ponimaskin, E., & Schachner, M. (2018). Cell adhesion molecule close homolog of L1 (CHL1) guides the regrowth of regenerating motor axons and regulates synaptic coverage of motor neurons. Frontiers in molecular neuroscience, 11, 174.

Katic, J., Loers, G., Tosic, J., Schachner, M., & Kleene, R. (2017). The cell adhesion molecule CHL1 interacts with patched-1 to regulate apoptosis during postnatal cerebellar development. Journal of cell science, 130(15), 2606-2619.

Alsanie, W. F., Penna, V., Schachner, M., Thompson, L. H., & Parish, C. L. (2017). Homophilic binding of the neural cell adhesion molecule CHL1 regulates development of ventral midbrain dopaminergic pathways. Scientific reports, 7(1), 1-10.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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