CHL1

The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. Several alternatively spliced transcript variants of this gene have been described, but their full length nature is not known. [provided by RefSeq]
Full Name
cell adhesion molecule with homology to L1CAM (close homolog of L1)
Function
Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity).
Biological Process
Axon guidance Source: InterPro
Axon regeneration Source: Ensembl
Cell adhesion Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Cell membrane. Soluble forms produced by cleavage/shedding also exist.
Processed neural cell adhesion molecule L1-like protein: Extracellular matrix
Topology
Extracellular: 25-1082
Helical: 1083-1103
Cytoplasmic: 1104-1208
PTM
Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors (By similarity). Cleaved by BACE1 (By similarity).
N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc) (By similarity).
O-glycosylated.
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Anti-CHL1 antibodies

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Rat Anti-CHL1 Recombinant Antibody (CBXC-1095) (CBMAB-C3632-CQ)

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Target: CHL1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Rat
Clone: CBXC-1095
Application*: WB
Datasheet SDS

Mouse Recombinant CHL1 protein, His Tag (V2LY-0526-LY8109)

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Target: CHL1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-1027
Tag: His Tag
Datasheet SDS

Mouse Recombinant CHL1 protein, hFc Tag (V2LY-0526-LY8108)

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Target: CHL1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-1027
Tag: hFc Tag
Datasheet SDS

Mouse Recombinant CHL1 protein (V2LY-0526-LY8107)

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Target: CHL1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-1027
Datasheet SDS

Human Recombinant CHL1 protein, His Tag (V2LY-0526-LY3123)

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Target: CHL1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-1080
Tag: His Tag
Datasheet SDS

Mouse Anti-CHL1 Recombinant Antibody (CBXC-1720) (CBMAB-C3631-CQ)

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Target: CHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1720
Application*: E
Datasheet SDS

Mouse Anti-CHL1 Recombinant Antibody (CBYY-C2062) (CBMAB-C3500-YY)

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Target: CHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2062
Application*: E
Datasheet SDS

Rat Anti-CHL1 Recombinant Antibody (CBYY-C2061) (CBMAB-C3499-YY)

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Target: CHL1
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2061
Application*: WB, IH
Datasheet SDS

Mouse Anti-CHL1 Recombinant Antibody (CBFYC-1839) (CBMAB-C1903-FY)

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Target: CHL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-1839
Application*: WB, IP, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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