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Mouse Anti-CHML Recombinant Antibody (5G4) (CBMAB-C7678-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
5G4
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa68-177 from human CHML.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CHM Like, Rab Escort Protein 2
Introduction
The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008]
Entrez Gene ID
1122
UniProt ID
P26374
Alternative Names
CHM Like, Rab Escort Protein 2; Choroideremia-Like (Rab Escort Protein 2); Choroideremia-Like Protein; REP2; Rab Proteins Geranylgeranyltransferase Component A 2; Choroideraemia-Like Protein; Rab Escort Protein 2; REP-2;
Function
Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.
Biological Process
Intracellular protein transport Source: InterPro
Positive regulation of GTPase activity Source: GOC
Post-translational protein modification Source: Reactome
Protein geranylgeranylation Source: UniProtKB
Small GTPase mediated signal transduction Source: InterPro
Vesicle-mediated transport Source: GO_Central
Cellular Location
Cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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