CHML

The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008]
Full Name
CHM Like, Rab Escort Protein 2
Function
Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.
Biological Process
Intracellular protein transport Source: InterPro
Positive regulation of GTPase activity Source: GOC
Post-translational protein modification Source: Reactome
Protein geranylgeranylation Source: UniProtKB
Small GTPase mediated signal transduction Source: InterPro
Vesicle-mediated transport Source: GO_Central
Cellular Location
Cytosol
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Anti-CHML antibodies

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Mouse Anti-CHML Recombinant Antibody (EG676) (CBMAB-EN817-LY)

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Target: CHML
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: EG676
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CHML Recombinant Antibody (5G4) (CBMAB-C7678-LY)

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Target: CHML
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5G4
Application*: E, WB
Datasheet SDS

CHML Matched Antibody Pair (269) (APMAB-269LY)

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Target: CHML
Specificity: Human
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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