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Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025)


See all CHRM3 antibodies
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Tested Data
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in IF
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in IF
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in FC
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in FC
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in FC
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in FC
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in IHC
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in IHC
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in IHC
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in IHC
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in IHC
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in IHC
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in IHC
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in IHC
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in IHC
Mouse Anti-CHRM3 Recombinant Antibody (CBT3289) (V2LY-0625-LY2025) in IHC

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rabbit
Clone
CBT3289
Antibody Isotype
IgG2a
Application
IHC, ICC, FC

Basic Information

Host Species
Mouse
Specificity
Human, Mouse, Rabbit
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
1131
UniProt ID
P20309
Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Biological Process
Acetylcholine receptor signaling pathway Source: ARUK-UCL
Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Source: GO_Central
Calcium-mediated signaling Source: ARUK-UCL
Cellular protein modification process Source: ProtInc
Chemical synaptic transmission Source: GO_Central
G protein-coupled acetylcholine receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Nervous system development Source: ProtInc
Positive regulation of smooth muscle contraction Source: InterPro
Regulation of ion transmembrane transporter activity Source: ARUK-UCL
Regulation of vascular associated smooth muscle contraction Source: GO_Central
Saliva secretion Source: InterPro
Signal transduction Source: ProtInc
Cellular Location
Endoplasmic reticulum membrane; Cell membrane; Postsynaptic cell membrane; Basolateral cell membrane. Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane.
Involvement in disease
Prune belly syndrome (PBS): A syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.
Topology
Extracellular: 1-67
Helical: 68-91
Cytoplasmic: 92-104
Helical: 105-130
Extracellular: 131-142
Helical: 143-164
Cytoplasmic: 165-184
Helical: 185-206
Extracellular: 207-229
Helical: 230-252
Cytoplasmic: 253-491
Helical: 492-514
Extracellular: 515-526
Helical: 527-546
Cytoplasmic: 547-590
More Infomation

Wan, J., Wang, J., & Wagner, L. E. (2021). Pancreas-specific CHRM3 activation causes pancreatitis in mice. JCI insight, 6(17).

Chen, J., Shin, V. Y., Cheuk, I., Siu, J., & Kwong, A. (2020). Abstract P1-07-01: Cholinergic receptor muscarinic 3 (CHRM3) contributes to breast cancer tumorigenesis through angiogenesis regulation.

Deng, A. Y., Huot-Marchard, J. É., deBlois, D., Thorin, E., Chauvet, C., & Menard, A. (2019). Functional dosage of muscarinic cholinergic receptor 3 signalling, not the gene dose, determines its hypertension pathogenesis. Canadian Journal of Cardiology, 35(5), 661-670.

Chee, L. Y., & Cumming, A. (2018). Polymorphisms in the cholinergic receptors muscarinic (CHRM2 and CHRM3) genes and Alzheimer’s disease. Avicenna journal of medical biotechnology, 10(3), 196.

Cowley Jr, A. W. (2018). Chrm3 Gene and M3 Muscarinic Receptors Contribute to Salt-Sensitive Hypertension: But Now a Physiological Puzzle. Hypertension, 72(3), 588-591.

Niwa, Y., Kanda, G. N., Yamada, R. G., Shi, S., Sunagawa, G. A., Ukai-Tadenuma, M., ... & Ueda, H. R. (2018). Muscarinic acetylcholine receptors Chrm1 and Chrm3 are essential for REM sleep. Cell Reports, 24(9), 2231-2247.

Deng, A. Y., deBlois, D., Laporte, S. A., Gelinas, D., Tardif, J. C., Thorin, E., ... & Ménard, A. (2018). Novel pathogenesis of hypertension and diastolic dysfunction caused by M3R (muscarinic cholinergic 3 receptor) signaling. Hypertension, 72(3), 755-764.

Patel, K. R., Bai, Y., Trieu, K. G., Barrios, J., & Ai, X. (2017). Targeting acetylcholine receptor M3 prevents the progression of airway hyperreactivity in a mouse model of childhood asthma. The FASEB Journal, 31(10), 4335-4346.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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