CHRM3

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities.

Full Name

CHOLINERGIC RECEPTOR MUSCARINIC 3

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Biological Process

Acetylcholine receptor signaling pathway Source: ARUK-UCL
Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Source: GO_Central
Calcium-mediated signaling Source: ARUK-UCL
Cellular protein modification process Source: ProtInc
Chemical synaptic transmission Source: GO_Central
G protein-coupled acetylcholine receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Nervous system development Source: ProtInc
Positive regulation of smooth muscle contraction Source: InterPro
Regulation of ion transmembrane transporter activity Source: ARUK-UCL
Regulation of vascular associated smooth muscle contraction Source: GO_Central
Saliva secretion Source: InterPro
Signal transduction Source: ProtInc

Cellular Location

Endoplasmic reticulum membrane; Cell membrane; Postsynaptic cell membrane; Basolateral cell membrane. Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane.

Involvement in disease

Prune belly syndrome (PBS): A syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.

Topology

Extracellular: 1-67
Helical: 68-91
Cytoplasmic: 92-104
Helical: 105-130
Extracellular: 131-142
Helical: 143-164
Cytoplasmic: 165-184
Helical: 185-206
Extracellular: 207-229
Helical: 230-252
Cytoplasmic: 253-491
Helical: 492-514
Extracellular: 515-526
Helical: 527-546
Cytoplasmic: 547-590