Mouse Anti-CHST11 Recombinant Antibody (CBFYC-1862) (CBMAB-C1926-FY)

Name: Mouse Anti-CHST11 Recombinant Antibody (CBFYC-1862)
SKU: CBMAB-C1926-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-1862

Application

ELISA, WB

Immunogen

CHST11 (230 a.a. ~ 337 a.a) partial recombinant protein.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 230-337

More Infomation

Target

Full Name

carbohydrate (chondroitin 4) sulfotransferase 11

Introduction

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

50515

UniProt ID

Q9NPF2

Alternative Names

Carbohydrate Sulfotransferase 11; Carbohydrate (Chondroitin 4) Sulfotransferase 11; Chondroitin 4-O-Sulfotransferase 1; Chondroitin 4-Sulfotransferase 1; EC 2.8.2.5; C4ST-1

Function

Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.

Biological Process

Carbohydrate biosynthetic process Source: InterPro
Chondrocyte development Source: Ensembl
Chondroitin sulfate biosynthetic process Source: UniProtKB
Developmental growth Source: Ensembl
Embryonic digit morphogenesis Source: Ensembl
Embryonic viscerocranium morphogenesis Source: Ensembl
In utero embryonic development Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
Polysaccharide localization Source: Ensembl
Post-anal tail morphogenesis Source: Ensembl
Post-embryonic development Source: Ensembl
Proteoglycan biosynthetic process Source: GO_Central
Regulation of cell population proliferation Source: Ensembl
Respiratory gaseous exchange by respiratory system Source: Ensembl

Cellular Location

Golgi apparatus membrane

Involvement in disease

A chromosomal aberration involving CHST11 is found in B-cell chronic lymphocytic leukemias. Translocation t(12;14)(q23;q32) with IgH.
Osteochondrodysplasia, brachydactyly, and overlapping malformed digits (OCBMD):
An autosomal recessive disorder characterized by bilateral symmetric skeletal defects that primarily affect the limbs. Affected individuals have mild short stature due to shortening of the lower leg bones, as well as hand and foot malformations, predominantly brachydactyly and overlapping digits. Other skeletal defects include scoliosis, dislocated patellae and fibulae, and pectus excavatum.

Topology

Cytoplasmic: 1-16
Helical: 17-37
Lumenal: 38-352

PTM

N-glycosylated; required for activity and stability.

Mamoor, S. (2021). Differential expression of carbohydrate (chondroitin 4) sulfotransferase 11 in human epithelial ovarian cancer.

Behrens, A., Jousheghany, F., Yao-Borengasser, A., Siegel, E. R., Kieber-Emmons, T., & Monzavi-Karbassi, B. (2020). Carbohydrate (chondroitin 4) sulfotransferase-11-mediated induction of epithelial-mesenchymal transition and generation of cancer stem cells. Pharmacology, 105(5-6), 246-259.

Zhang, L., Shi, R., Ouyang, H., & Li, Y. (2020). Cloning and characterization of chst11 from Procambarus clarkii involved in the host immune response of white spot syndrome virus and Aeromonas hydrophila. Fish & shellfish immunology, 102, 82-91.

Shabbir, R. M. K., Nalbant, G., Ahmad, N., Malik, S., & Tolun, A. (2018). Homozygous CHST11 mutation in chondrodysplasia, brachydactyly, overriding digits, clino-symphalangism and synpolydactyly. Journal of medical genetics, 55(7), 489-496.

Wang, Q., Yang, C., Hao, R., Zheng, Z., Jiao, Y., Du, X., ... & Huang, R. (2017). Molecular characterization of CHST11 and its potential role in nacre formation in pearl oyster Pinctada fucata martensii. Electronic Journal of Biotechnology, 28, 113-119.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Human Recombinant CHST11 protein, His Tag (CAT#: V2LY-0526-LY3132)

Human CHST11 ELISA Kit (CAT#: V2LY-0626-LY3494)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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