Human CHST11 ELISA Kit (V2LY-0626-LY3494)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
10.11 ml
Detection Range
0.02-6 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
41.6 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
carbohydrate (chondroitin 4) sulfotransferase 11
Function
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
Biological Process
Carbohydrate biosynthetic process Source: InterPro
Chondrocyte development Source: Ensembl
Chondroitin sulfate biosynthetic process Source: UniProtKB
Developmental growth Source: Ensembl
Embryonic digit morphogenesis Source: Ensembl
Embryonic viscerocranium morphogenesis Source: Ensembl
In utero embryonic development Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
Polysaccharide localization Source: Ensembl
Post-anal tail morphogenesis Source: Ensembl
Post-embryonic development Source: Ensembl
Proteoglycan biosynthetic process Source: GO_Central
Regulation of cell population proliferation Source: Ensembl
Respiratory gaseous exchange by respiratory system Source: Ensembl
Cellular Location
Golgi apparatus membrane
Involvement in disease
A chromosomal aberration involving CHST11 is found in B-cell chronic lymphocytic leukemias. Translocation t(12;14)(q23;q32) with IgH.
Osteochondrodysplasia, brachydactyly, and overlapping malformed digits (OCBMD):
An autosomal recessive disorder characterized by bilateral symmetric skeletal defects that primarily affect the limbs. Affected individuals have mild short stature due to shortening of the lower leg bones, as well as hand and foot malformations, predominantly brachydactyly and overlapping digits. Other skeletal defects include scoliosis, dislocated patellae and fibulae, and pectus excavatum.
Topology
Cytoplasmic: 1-16
Helical: 17-37
Lumenal: 38-352
PTM
N-glycosylated; required for activity and stability.

Mamoor, S. (2021). Differential expression of carbohydrate (chondroitin 4) sulfotransferase 11 in human epithelial ovarian cancer.

Behrens, A., Jousheghany, F., Yao-Borengasser, A., Siegel, E. R., Kieber-Emmons, T., & Monzavi-Karbassi, B. (2020). Carbohydrate (chondroitin 4) sulfotransferase-11-mediated induction of epithelial-mesenchymal transition and generation of cancer stem cells. Pharmacology, 105(5-6), 246-259.

Zhang, L., Shi, R., Ouyang, H., & Li, Y. (2020). Cloning and characterization of chst11 from Procambarus clarkii involved in the host immune response of white spot syndrome virus and Aeromonas hydrophila. Fish & shellfish immunology, 102, 82-91.

Shabbir, R. M. K., Nalbant, G., Ahmad, N., Malik, S., & Tolun, A. (2018). Homozygous CHST11 mutation in chondrodysplasia, brachydactyly, overriding digits, clino-symphalangism and synpolydactyly. Journal of medical genetics, 55(7), 489-496.

Wang, Q., Yang, C., Hao, R., Zheng, Z., Jiao, Y., Du, X., ... & Huang, R. (2017). Molecular characterization of CHST11 and its potential role in nacre formation in pearl oyster Pinctada fucata martensii. Electronic Journal of Biotechnology, 28, 113-119.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CHST11 protein, His Tag (CAT#: V2LY-0526-LY3132)

Related Products

Human Recombinant CHST11 protein, His Tag (CAT#: V2LY-0526-LY3132)

Mouse Anti-CHST11 Recombinant Antibody (CBFYC-1862) (CAT#: CBMAB-C1926-FY)

Mouse Anti-CHST11 Recombinant Antibody (CBFYC-1861) (CAT#: CBMAB-C1925-FY)

Isotype control

For research use only. Not intended for any clinical use.

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