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Mouse Anti-CISD1 Recombinant Antibody (1A8) (CBMAB-C0472-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1A8
Antibody Isotype
IgG1, κ
Application
WB, ELISA, IP, FC

Basic Information

Immunogen
Recombinant protein corresponding to amino acids 32-108 of mitoNEET of human.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CDGSH Iron Sulfur Domain 1
Introduction
This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Feb 2012]
Entrez Gene ID
55847
UniProt ID
Q9NZ45
Alternative Names
CDGSH Iron Sulfur Domain 1; MitoNEET; C10orf70; ZCD1; CDGSH Iron-Sulfur Domain-Containing Protein 1; Chromosome 10 Open Reading Frame 70; Zinc Finger, CDGSH-Type Domain 1; Zinc Finger CDGSH-Type Domain 1; MDS029;
Function
Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity).

May be involved in Fe-S cluster shuttling and/or in redox reactions.
Biological Process
Regulation of cellular respiration Source: Ensembl
Cellular Location
Mitochondrion outer membrane
Topology
Helical: 14-31
Cytoplasmic: 32-108
PTM
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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