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Rabbit Anti-CISD1 Recombinant Antibody (CBWJZ-058) (CBMAB-Z0127-WJ)

This product is a rabbit antibody that recognizes CISD1. The antibody CBWJZ-058 can be used for immunoassay techniques such as: WB, IP.
See all CISD1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBWJZ-058
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
CDGSH Iron Sulfur Domain 1
Introduction
CISD1 (CDGSH Iron Sulfur Domain 1) is a Protein Coding gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. Diseases associated with CISD1 include Wolfram Syndrome. Among its related pathways are Adipogenesis and Glucose / Energy Metabolism.
Entrez Gene ID
Human55847
Mouse52637
Rat294362
UniProt ID
HumanQ9NZ45
MouseQ91WS0
RatB0K020
Alternative Names
CD1; MDS029; C10orf70; mitoNEET
Function
Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity).

May be involved in Fe-S cluster shuttling and/or in redox reactions.
Biological Process
Regulation of cellular respiration Source: Ensembl
Cellular Location
Mitochondrion outer membrane
Topology
Helical: 14-31
Cytoplasmic: 32-108
PTM
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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