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Rabbit Anti-CISD1 Recombinant Antibody (CBWJZ-058) (CBMAB-Z0127-WJ)

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Published Data
CBMAB-Z0127-WJ-1
Rabbit Anti-CISD1 Recombinant Antibody (CBWJZ-058) (CBMAB-Z0127-WJ) in IHC
The expression of CISD1 in LUAD tissue was examined by IHC assay. ...View More
Jiang, X., Yuan, Y., Tang, L., Wang, J., Zhang, D., & Duan, L. (2022). Systematic analysis and validation of the prognosis, immunological role and biology function of the ferroptosis-related lncRNA GSEC/miRNA-101-3p/CISD1 axis in lung adenocarcinoma. Frontiers in Molecular Biosciences, 8, 793732.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-Z0127-WJ-2
Rabbit Anti-CISD1 Recombinant Antibody (CBWJZ-058) (CBMAB-Z0127-WJ) in WB
Representative Western blots for OXPHOS, from heart or skeletal muscle tissue (n = 5), with quantitation shown in the graph for complex I-V. Representative Western blots for TOM20, n = 4; mitoNEET, n = 4; tDRP1, n = 4; OPA1, n = 3; Ferritin, n = 4; mitoFerritin, n = 4 in both th3/+ and WT groups, with quantitative analysis shown in graphs as mean ± SEM. ...View More
Reboucas, P., Fillebeen, C., Botta, A., Cleverdon, R., Steele, A. P., Richard, V., ... & Sweeney, G. (2023). Discovery-Based Proteomics Identify Skeletal Muscle Mitochondrial Alterations as an Early Metabolic Defect in a Mouse Model of β-Thalassemia. International Journal of Molecular Sciences, 24(5), 4402.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-Z0127-WJ-3
Rabbit Anti-CISD1 Recombinant Antibody (CBWJZ-058) (CBMAB-Z0127-WJ) in WB
Western blotting for MitoNEET in EV and MitoN cells showed expression of the exogenous flagged-tagged MitoNEET (13 kDa) relative to the endogenous version (12 kDa). ...View More
Tam, E., Sung, H. K., Lam, N. H., You, S., Cho, S., Ahmed, S. M., ... & Sweeney, G. (2022). Role of mitochondrial iron overload in mediating cell death in H9c2 cells. Cells, 12(1), 118.
Distributed under Open Access license CC BY 4.0, without modification.
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
CBWJZ-058
Application
WB, IP
Immunogen
Synthetic peptide corresponding to residues surrounding Asp61 of human CISD1/mitoNEET protein.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IP1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 100ug/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
More Infomation

Target

Full Name
CDGSH Iron Sulfur Domain 1
Introduction
CISD1 (CDGSH Iron Sulfur Domain 1) is a Protein Coding gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. Diseases associated with CISD1 include Wolfram Syndrome. Among its related pathways are Adipogenesis and Glucose / Energy Metabolism.
Entrez Gene ID
Human55847
Mouse52637
Rat294362
UniProt ID
HumanQ9NZ45
MouseQ91WS0
RatB0K020
Alternative Names
CD1; MDS029; C10orf70; mitoNEET
Function
Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity).

May be involved in Fe-S cluster shuttling and/or in redox reactions.
Biological Process
Regulation of cellular respiration Source: Ensembl
Cellular Location
Mitochondrion outer membrane
Topology
Helical: 14-31
Cytoplasmic: 32-108
PTM
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

Hua, J., Gao, Z., Zhong, S., Wei, B., Zhu, J., & Ying, R. (2021). CISD1 protects against atherosclerosis by suppressing lipid accumulation and inflammation via mediating Drp1. Biochemical and Biophysical Research Communications, 577, 80-88.

Hsiung, K. C., Liu, K. Y., Tsai, T. F., Yoshina, S., Mitani, S., Tan, B. C. M., & Lo, S. J. (2020). Defects in CISD-1, a mitochondrial iron-sulfur protein, lower glucose level and ATP production in Caenorhabditis elegans. Biomedical journal, 43(1), 32-43.

Sengupta, S., Nechushtai, R., Jennings, P. A., Jose’N, O., Padilla, P. A., Azad, R. K., & Mittler, R. (2018). Phylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin. Scientific reports, 8(1), 1-12.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-CISD1 Recombinant Antibody (1A8) (CAT#: CBMAB-C0472-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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