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Rabbit Anti-CLDN18 Recombinant Antibody (CBYY-C3110) (V2LY-1206-LY16)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYY-C3110
Antibody Isotype
IgG
Application
IHC

Basic Information

Immunogen
Recombinant fragment (aa1-100) of human Claudin-18.2 protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IHC1-2 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA
Preservative
0.02% sodium azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Claudin 18
Entrez Gene ID
51208
UniProt ID
P56856
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Digestive tract development Source: Ensembl
Negative regulation of bone resorption Source: Ensembl
Negative regulation of osteoclast development Source: Ensembl
Negative regulation of protein localization to nucleus Source: Ensembl
Response to ethanol Source: Ensembl
TNFSF11-mediated signaling pathway Source: Ensembl
Cellular Location
Cell membrane; Tight junction. Localizes to tight junctions in epithelial cells.
Topology
Cytoplasmic: 1-6
Helical: 7-27
Extracellular: 28-80
Helical: 81-101
Cytoplasmic: 102-122
Helical: 123-143
Extracellular: 144-174
Helical: 175-195
Cytoplasmic: 196-261
More Infomation

Iwaya, M., Hayashi, H., Nakajima, T., Matsuda, K., Kinugawa, Y., Tobe, Y., ... & Ota, H. (2021). Colitis‐associated colorectal adenocarcinomas frequently express claudin 18 isoform 2: implications for claudin 18.2 monoclonal antibody therapy. Histopathology, 79(2), 227-237.

Caron, T. J., Scott, K. E., Sinha, N., Muthupalani, S., Baqai, M., Ang, L. H., ... & Hagen, S. J. (2021). Claudin-18 Loss Alters Transcellular Chloride Flux but not Tight Junction Ion Selectivity in Gastric Epithelial Cells. Cellular and Molecular Gastroenterology and Hepatology, 11(3), 783-801.

Sato, K., Matsumoto, I., Suzuki, K., Tamura, A., Shiraishi, A., Kiyonari, H., ... & Kawakami, K. (2021). Deficiency of lung-specific claudin-18 leads to aggravated infection with Cryptococcus deneoformans through dysregulation of the microenvironment in lungs. Scientific reports, 11(1), 1-13.

Lee, P. H., Hong, J., & Jang, A. S. (2020). N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression. The Korean journal of internal medicine, 35(5), 1229.

Coati, I., Lotz, G., Fanelli, G. N., Brignola, S., Lanza, C., Cappellesso, R., ... & Fassan, M. (2019). Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases. British journal of cancer, 121(3), 257-263.

Hagen, S. J., Ang, L. H., Zheng, Y., Karahan, S. N., Wu, J., Wang, Y. E., ... & Fox, J. G. (2018). Loss of tight junction protein claudin 18 promotes progressive neoplasia development in mouse stomach. Gastroenterology, 155(6), 1852-1867.

Zhou, B., Flodby, P., Luo, J., Castillo, D. R., Liu, Y., Yu, F. X., ... & Borok, Z. (2018). Claudin-18–mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. The Journal of clinical investigation, 128(3), 970-984.

Kotton, D. N. (2018). Claudin-18: unexpected regulator of lung alveolar epithelial cell proliferation. The Journal of clinical investigation, 128(3), 903-905.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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