CLDN18

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
Full Name
Claudin 18
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Digestive tract development Source: Ensembl
Negative regulation of bone resorption Source: Ensembl
Negative regulation of osteoclast development Source: Ensembl
Negative regulation of protein localization to nucleus Source: Ensembl
Response to ethanol Source: Ensembl
TNFSF11-mediated signaling pathway Source: Ensembl
Cellular Location
Cell membrane; Tight junction. Localizes to tight junctions in epithelial cells.
Topology
Cytoplasmic: 1-6
Helical: 7-27
Extracellular: 28-80
Helical: 81-101
Cytoplasmic: 102-122
Helical: 123-143
Extracellular: 144-174
Helical: 175-195
Cytoplasmic: 196-261
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Anti-CLDN18 antibodies

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Rabbit Anti-CLDN18 Recombinant Antibody (C5556) (CBMAB-C5556-LY)

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Target: CLDN18
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: C5556
Application*: P
Datasheet SDS

Human CLDN18 ELISA Kit (V2LY-0626-LY4248)

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Target: CLDN18
Sensitivity: 0.019 ng/mL
Detection Range: 0.03-9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Recombinant CLDN18-VLP protein, His & Strep Tag (V2LY-0526-LY8119)

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Target: CLDN18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 2-264
Tag: His & Strep Tag
Datasheet SDS

Human Recombinant CLDN18, Detergent protein, Biotin Conjugated, AVI & Flag Tag (V2LY-0526-LY3202)

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Target: CLDN18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-261
Tag: AVI & Flag Tag
Datasheet SDS

Human Recombinant CLDN18, Nanodisc protein, His & Strep Tag (V2LY-0526-LY3201)

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Target: CLDN18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-261
Tag: His & Strep Tag
Datasheet SDS

Human Recombinant CLDN18 protein, His & Flag Tag (V2LY-0526-LY3199)

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Target: CLDN18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-261
Tag: His & Flag Tag
Datasheet SDS

Human Recombinant CLDN18, Detergent protein, Flag & AVI Tag (V2LY-0526-LY3197)

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Target: CLDN18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-200
Tag: Flag & AVI Tag
Datasheet SDS

Human Recombinant CLDN18-VLP protein, Fluorescent Conjugated, (V2LY-0526-LY3200)

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Target: CLDN18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-261
Datasheet SDS

Human Recombinant CLDN18-VLP protein-1 (V2LY-0526-LY3198)

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Target: CLDN18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-261
Datasheet SDS

Human Recombinant CLDN18-VLP protein (V2LY-0526-LY159)

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Target: CLDN18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-261
Datasheet SDS

Human Anti-CLDN18 Recombinant Antibody (
25E3) (V2LY-0725-LY664)

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Target: CLDN18
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 25E3
Application*: E, F
Datasheet SDS

Mouse Anti-CLDN18 Recombinant Antibody (
2F8) (V2LY-0725-LY275)

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Target: CLDN18
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: 2F8
Application*: E, IH
Datasheet SDS

Human Anti-CLDN18 Recombinant Antibody (
9C2) (V2LY-0725-LY663)

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Target: CLDN18
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 9C2
Application*: E, F
Datasheet SDS

Mouse Anti-CLDN18 Recombinant Antibody (AP1533) (V2LY-1206-LY19)

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Target: CLDN18
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: AP1533
Application*: E, P
Datasheet SDS

Human Anti-CLDN18 Recombinant Antibody (CF102) (V2LY-1206-LY18)

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Target: CLDN18
Host: Human
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CF102
Application*: F
Datasheet SDS

Human Anti-CLDN18 Recombinant Antibody (CB112A) (V2LY-1206-LY17)

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Target: CLDN18
Host: Human
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CB112A
Application*: in vivo
In Vivo Assay
Datasheet SDS

Rabbit Anti-CLDN18 Recombinant Antibody (CBYY-C3110) (V2LY-1206-LY16)

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Target: CLDN18
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C3110
Application*: IH
Datasheet SDS

Mouse Anti-CLDN18 Recombinant Antibody (CBXC-2958) (V2LY-1206-LY15)

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Target: CLDN18
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2958
Application*: P
Datasheet SDS

Mouse Anti-CLDN18 Monoclonal Antibody (CBFYR-0014) (V2LY-1206-LY13)

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Target: CLDN18
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYR-0014
Application*: WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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