Human Recombinant CLDN18 protein, His & Flag Tag (V2LY-0526-LY3199)

Name: Human Recombinant CLDN18 protein, His & Flag Tag
SKU: V2LY-0526-LY3199
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His & Flag Tag

Protein Construction

This product is Human Recombinant CLDN18 protein, His & Flag Tag consist of Amino Acid: 1-261 and predicts a molecular mass of 30.54 kDa.

Molecule Mass

30.54 kDa

Sequence

Amino Acid: 1-261

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥75% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -70°C or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Claudin 18

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Biological Process

Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Digestive tract development Source: Ensembl
Negative regulation of bone resorption Source: Ensembl
Negative regulation of osteoclast development Source: Ensembl
Negative regulation of protein localization to nucleus Source: Ensembl
Response to ethanol Source: Ensembl
TNFSF11-mediated signaling pathway Source: Ensembl

Cellular Location

Cell membrane; Tight junction. Localizes to tight junctions in epithelial cells.

Topology

Cytoplasmic: 1-6
Helical: 7-27
Extracellular: 28-80
Helical: 81-101
Cytoplasmic: 102-122
Helical: 123-143
Extracellular: 144-174
Helical: 175-195
Cytoplasmic: 196-261

Iwaya, M., Hayashi, H., Nakajima, T., Matsuda, K., Kinugawa, Y., Tobe, Y., ... & Ota, H. (2021). Colitis‐associated colorectal adenocarcinomas frequently express claudin 18 isoform 2: implications for claudin 18.2 monoclonal antibody therapy. Histopathology, 79(2), 227-237.

Caron, T. J., Scott, K. E., Sinha, N., Muthupalani, S., Baqai, M., Ang, L. H., ... & Hagen, S. J. (2021). Claudin-18 Loss Alters Transcellular Chloride Flux but not Tight Junction Ion Selectivity in Gastric Epithelial Cells. Cellular and Molecular Gastroenterology and Hepatology, 11(3), 783-801.

Sato, K., Matsumoto, I., Suzuki, K., Tamura, A., Shiraishi, A., Kiyonari, H., ... & Kawakami, K. (2021). Deficiency of lung-specific claudin-18 leads to aggravated infection with Cryptococcus deneoformans through dysregulation of the microenvironment in lungs. Scientific reports, 11(1), 1-13.

Lee, P. H., Hong, J., & Jang, A. S. (2020). N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression. The Korean journal of internal medicine, 35(5), 1229.

Coati, I., Lotz, G., Fanelli, G. N., Brignola, S., Lanza, C., Cappellesso, R., ... & Fassan, M. (2019). Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases. British journal of cancer, 121(3), 257-263.

Hagen, S. J., Ang, L. H., Zheng, Y., Karahan, S. N., Wu, J., Wang, Y. E., ... & Fox, J. G. (2018). Loss of tight junction protein claudin 18 promotes progressive neoplasia development in mouse stomach. Gastroenterology, 155(6), 1852-1867.

Zhou, B., Flodby, P., Luo, J., Castillo, D. R., Liu, Y., Yu, F. X., ... & Borok, Z. (2018). Claudin-18–mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. The Journal of clinical investigation, 128(3), 970-984.

Kotton, D. N. (2018). Claudin-18: unexpected regulator of lung alveolar epithelial cell proliferation. The Journal of clinical investigation, 128(3), 903-905.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CLDN18-VLP protein (CAT#: V2LY-0526-LY159)

Human Recombinant CLDN18-VLP protein-1 (CAT#: V2LY-0526-LY3198)

Human Recombinant CLDN18-VLP protein, Fluorescent Conjugated, (CAT#: V2LY-0526-LY3200)

Human Recombinant CLDN18, Detergent protein, Flag & AVI Tag (CAT#: V2LY-0526-LY3197)

Human Recombinant CLDN18, Nanodisc protein, His & Strep Tag (CAT#: V2LY-0526-LY3201)

Human Recombinant CLDN18, Detergent protein, Biotin Conjugated, AVI & Flag Tag (CAT#: V2LY-0526-LY3202)

Mouse Recombinant CLDN18-VLP protein, His & Strep Tag (CAT#: V2LY-0526-LY8119)

Human CLDN18 ELISA Kit (CAT#: V2LY-0626-LY4248)

Related Products

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Mouse Recombinant CLDN18-VLP protein, His & Strep Tag (CAT#: V2LY-0526-LY8119)

Rabbit Anti-CLDN18 Recombinant Antibody (CBYY-C3110) (CAT#: V2LY-1206-LY16)

Mouse Anti-CLDN18 Recombinant Antibody (CBXC-2958) (CAT#: V2LY-1206-LY15)

Human CLDN18 ELISA Kit (CAT#: V2LY-0626-LY4248)

Human Recombinant CLDN18, Detergent protein, Flag & AVI Tag (CAT#: V2LY-0526-LY3197)

Human Recombinant CLDN18-VLP protein (CAT#: V2LY-0526-LY159)

Human Recombinant CLDN18-VLP protein, Fluorescent Conjugated, (CAT#: V2LY-0526-LY3200)

Human Recombinant CLDN18, Nanodisc protein, His & Strep Tag (CAT#: V2LY-0526-LY3201)

Mouse Anti-CLDN18 Recombinant Antibody (AP1533) (CAT#: V2LY-1206-LY19)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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